Vše

Co hledáte?

Vše
Projekty
Výsledky výzkumu
Subjekty

Rychlé hledání

  • Projekty podpořené TA ČR
  • Významné projekty
  • Projekty s nejvyšší státní podporou
  • Aktuálně běžící projekty

Chytré vyhledávání

  • Takto najdu konkrétní +slovo
  • Takto z výsledků -slovo zcela vynechám
  • “Takto můžu najít celou frázi”

Search for biomarkers of Alzheimer's disease: Recent insights, current challenges and future prospects

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43918845" target="_blank" >RIV/60461373:22340/19:43918845 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/19:10400049 RIV/00064165:_____/19:10400049

  • Výsledek na webu

    <a href="https://www.sciencedirect.com/science/article/pii/S0009912018311858?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009912018311858?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clinbiochem.2019.04.002" target="_blank" >10.1016/j.clinbiochem.2019.04.002</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Search for biomarkers of Alzheimer's disease: Recent insights, current challenges and future prospects

  • Popis výsledku v původním jazyce

    Due to the trend of prolonged lifespan leading to higher incidence of age-related diseases, the demand for reliable biomarkers of dementia rises. In this review, we present novel biomarkers of high potential, especially those found in blood, urine or saliva, which could lead to a more comfortable patient experience and better time- and cost-effectivity, compared to the currently used diagnostic methods. We focus on biomarkers that might allow for the detection of Alzheimer&apos;s disease before its clinical manifestations. Such biomarkers might be helpful for better understanding the etiology of the disease and identifying its risk factors. Moreover, it could be a base for developing new treatment or at least help to prolong the presymptomatic stage in patients suffering from Alzheimer&apos;s disease. As potential candidates, we present, for instance, neurofilament light in both cerebrospinal fluid and blood plasma or amyloid beta in plasma. Above all, we provide an overview of different approaches to the diagnostics, analyzing patient&apos;s biofluids as a whole using molecular spectroscopy. Infrared and Raman spectroscopy and especially chiroptical methods provide information not only on the chemical composition, but also on molecular structure. Therefore, these techniques are promising for the diagnostics of Alzheimer&apos;s disease, as the accumulation of amyloid beta in abnormal conformation is one of the hallmarks of this disease.

  • Název v anglickém jazyce

    Search for biomarkers of Alzheimer's disease: Recent insights, current challenges and future prospects

  • Popis výsledku anglicky

    Due to the trend of prolonged lifespan leading to higher incidence of age-related diseases, the demand for reliable biomarkers of dementia rises. In this review, we present novel biomarkers of high potential, especially those found in blood, urine or saliva, which could lead to a more comfortable patient experience and better time- and cost-effectivity, compared to the currently used diagnostic methods. We focus on biomarkers that might allow for the detection of Alzheimer&apos;s disease before its clinical manifestations. Such biomarkers might be helpful for better understanding the etiology of the disease and identifying its risk factors. Moreover, it could be a base for developing new treatment or at least help to prolong the presymptomatic stage in patients suffering from Alzheimer&apos;s disease. As potential candidates, we present, for instance, neurofilament light in both cerebrospinal fluid and blood plasma or amyloid beta in plasma. Above all, we provide an overview of different approaches to the diagnostics, analyzing patient&apos;s biofluids as a whole using molecular spectroscopy. Infrared and Raman spectroscopy and especially chiroptical methods provide information not only on the chemical composition, but also on molecular structure. Therefore, these techniques are promising for the diagnostics of Alzheimer&apos;s disease, as the accumulation of amyloid beta in abnormal conformation is one of the hallmarks of this disease.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10406 - Analytical chemistry

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/GA17-05292S" target="_blank" >GA17-05292S: Nové krevní biomarkery pro včasnou diagnostiku, prognózu a průběh Alzheimerovy nemoci</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2019

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Clinical Biochemistry

  • ISSN

    0009-9120

  • e-ISSN

  • Svazek periodika

    72

  • Číslo periodika v rámci svazku

    OCT 2019

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    13

  • Strana od-do

    39-51

  • Kód UT WoS článku

    000486413800007

  • EID výsledku v databázi Scopus

    2-s2.0-85064078438