Population balance modelling and experimental investigation of reactive dissolution of microparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43919307" target="_blank" >RIV/60461373:22340/19:43919307 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Population balance modelling and experimental investigation of reactive dissolution of microparticles

Popis výsledku v původním jazyce

Dissolution testing is widely used to predict the in-vitro performance of crystalline drugs, during the drug formulation process. However, to achieve a desired dissolution rate, many time-consuming experiments need to be conducted, because dissolution strongly depends on particle size. To eliminate the need of such experiments, we suggest a discretized population balance model, which predicts the evolution of particle size distribution and reactive dissolution over time. The model is based on a growth rate expression, derived from Noyes-Whitney equation, setting the relationship between the particle size and solubility. This expression was incorporated in a for-loop system, required to simulate the behavior of PSD and dissolution rate over time. The model evaluated two different cases: monomodal and bimodal distribution. In parallel to the model, in vitro experiments were carried out. Crystalline KCl was used as a reference compound, because KCl experiments are less time consuming. Nevertheless, its dissolution mechanism is similar to a crystalline drug. Real time changes of PSD and dissolution rate of KCl were measured in a stirred flow cell of LDA. Simulation results were compared to experimental ones for validation, by fitting two unknown parameters (diffusion coefficient and particle velocity). Our results indicate that the model is able to predict reactive dissolution and simulate similar evolution of PSD over time, in agreement with the experimental data measured.

Název v anglickém jazyce

Population balance modelling and experimental investigation of reactive dissolution of microparticles

Popis výsledku anglicky

Dissolution testing is widely used to predict the in-vitro performance of crystalline drugs, during the drug formulation process. However, to achieve a desired dissolution rate, many time-consuming experiments need to be conducted, because dissolution strongly depends on particle size. To eliminate the need of such experiments, we suggest a discretized population balance model, which predicts the evolution of particle size distribution and reactive dissolution over time. The model is based on a growth rate expression, derived from Noyes-Whitney equation, setting the relationship between the particle size and solubility. This expression was incorporated in a for-loop system, required to simulate the behavior of PSD and dissolution rate over time. The model evaluated two different cases: monomodal and bimodal distribution. In parallel to the model, in vitro experiments were carried out. Crystalline KCl was used as a reference compound, because KCl experiments are less time consuming. Nevertheless, its dissolution mechanism is similar to a crystalline drug. Real time changes of PSD and dissolution rate of KCl were measured in a stirred flow cell of LDA. Simulation results were compared to experimental ones for validation, by fitting two unknown parameters (diffusion coefficient and particle velocity). Our results indicate that the model is able to predict reactive dissolution and simulate similar evolution of PSD over time, in agreement with the experimental data measured.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/GX19-26127X" target="_blank" >GX19-26127X: Robotický nano-lékárník: Výrobní procesy budoucnosti pro personalisovaná terapeutika</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings 46th International Conference of the Slovak Society of Chemical Engineering

ISBN

978-80-8208-011-0

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

32

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare

Datum konání akce

20. 5. 2019

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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