Development of Hot-Melt Extrusion Method to Produce Hydroxyapatite/Polycaprolactone Composite Filaments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922352" target="_blank" >RIV/60461373:22340/21:43922352 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22350/21:43922352

Výsledek na webu

<a href="https://doi.org/10.1002/adem.202100820" target="_blank" >https://doi.org/10.1002/adem.202100820</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adem.202100820" target="_blank" >10.1002/adem.202100820</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Development of Hot-Melt Extrusion Method to Produce Hydroxyapatite/Polycaprolactone Composite Filaments

Popis výsledku v původním jazyce

The aim of this work is to develop a single-step process to produce hydroxyapatite/polycaprolactone (HAp/PCL) composite filaments for 3D printing of bone scaffolds by fused deposition modeling (FDM). The HAp/PCL composite filaments are produced by hot-melt extrusion, with direct in situ blending. For practical purposes, the effect of PCL particle size on filament homogeneity and printability is assessed between PCL in powder and pellet form. The effect of HAp content on processing parameters and filament properties is also evaluated. Filament extrudability, homogeneity, and shape consistency improve with increasing HAp content up to a threshold of 40 wt%. Furthermore, an optimal range of the composite melt viscosity for the extrusion process is defined. The produced filaments are successfully 3D printed by FDM and the resulting prototypes show improved compressive modulus and degradation rate with increasing HAp content. A cytocompatibility assay is conducted, which suggests an optimal HAp content to be less than 40 wt% in terms of cell viability, adhesion, and proliferation. The developed method offers several advantages, as it completely avoids the use of toxic solvents and enables the incorporation of very high HAp concentrations, further improving the chances of implementation of FDM for bone tissue regeneration medicine. © 2021 Wiley-VCH GmbH

Název v anglickém jazyce

Development of Hot-Melt Extrusion Method to Produce Hydroxyapatite/Polycaprolactone Composite Filaments

Popis výsledku anglicky

The aim of this work is to develop a single-step process to produce hydroxyapatite/polycaprolactone (HAp/PCL) composite filaments for 3D printing of bone scaffolds by fused deposition modeling (FDM). The HAp/PCL composite filaments are produced by hot-melt extrusion, with direct in situ blending. For practical purposes, the effect of PCL particle size on filament homogeneity and printability is assessed between PCL in powder and pellet form. The effect of HAp content on processing parameters and filament properties is also evaluated. Filament extrudability, homogeneity, and shape consistency improve with increasing HAp content up to a threshold of 40 wt%. Furthermore, an optimal range of the composite melt viscosity for the extrusion process is defined. The produced filaments are successfully 3D printed by FDM and the resulting prototypes show improved compressive modulus and degradation rate with increasing HAp content. A cytocompatibility assay is conducted, which suggests an optimal HAp content to be less than 40 wt% in terms of cell viability, adhesion, and proliferation. The developed method offers several advantages, as it completely avoids the use of toxic solvents and enables the incorporation of very high HAp concentrations, further improving the chances of implementation of FDM for bone tissue regeneration medicine. © 2021 Wiley-VCH GmbH

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/TJ02000383" target="_blank" >TJ02000383: Metoda výroby lékové formy, personalizované pro potřeby konkrétního pacienta za pomoci matematické simulace a 3D tisku</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ADVANCED ENGINEERING MATERIALS

ISSN

1438-1656

e-ISSN

—

Svazek periodika

2100820

Číslo periodika v rámci svazku

07.09.2021

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

000695778200001

EID výsledku v databázi Scopus

2-s2.0-85114852077