Frequency analysis of stress relaxation patterns reveals the effect of formulation and process history on tablet disintegration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922864" target="_blank" >RIV/60461373:22340/21:43922864 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.powtec.2020.10.081" target="_blank" >https://doi.org/10.1016/j.powtec.2020.10.081</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2020.10.081" target="_blank" >10.1016/j.powtec.2020.10.081</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Frequency analysis of stress relaxation patterns reveals the effect of formulation and process history on tablet disintegration

Popis výsledku v původním jazyce

Tablets are the most common pharmaceutical dosage form. Being compressed from smaller particles or granules, the disintegration rate of tablets in the gastro-intestinal tract is a key property that strongly influences the rate of drug release. While established methods for in vitro tablet disintegration measurement provide information about the final disintegration time, a more detailed analysis of the disintegration process can be a rich source of additional information. In this work, a new method of tablet disintegration monitoring based on real-time recording of stress relaxation curves in tablets after immersion in the dissolution medium is presented. The signal is recorded using a texture analyzer with a needle probe, and then processed to reveal structural changes in the disintegrating tablet. It is shown that the frequency and amplitude of fluctuations on the stress relaxation curve are uniquely able to capture parameters such as the disintegrant content and the particle size of the drug and excipients from which the tablet was made. Moreover, the method is highly sensitive to variations in the composition of dissolution media; it can therefore be used during formulation development, biopharmaceutical analysis and for the general understanding of process-property relationships of compacted granular materials. © 2020

Název v anglickém jazyce

Frequency analysis of stress relaxation patterns reveals the effect of formulation and process history on tablet disintegration

Popis výsledku anglicky

Tablets are the most common pharmaceutical dosage form. Being compressed from smaller particles or granules, the disintegration rate of tablets in the gastro-intestinal tract is a key property that strongly influences the rate of drug release. While established methods for in vitro tablet disintegration measurement provide information about the final disintegration time, a more detailed analysis of the disintegration process can be a rich source of additional information. In this work, a new method of tablet disintegration monitoring based on real-time recording of stress relaxation curves in tablets after immersion in the dissolution medium is presented. The signal is recorded using a texture analyzer with a needle probe, and then processed to reveal structural changes in the disintegrating tablet. It is shown that the frequency and amplitude of fluctuations on the stress relaxation curve are uniquely able to capture parameters such as the disintegrant content and the particle size of the drug and excipients from which the tablet was made. Moreover, the method is highly sensitive to variations in the composition of dissolution media; it can therefore be used during formulation development, biopharmaceutical analysis and for the general understanding of process-property relationships of compacted granular materials. © 2020

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/GX19-26127X" target="_blank" >GX19-26127X: Robotický nano-lékárník: Výrobní procesy budoucnosti pro personalisovaná terapeutika</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder Technology

ISSN

0032-5910

e-ISSN

—

Svazek periodika

379

Číslo periodika v rámci svazku

February 2021

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

438-446

Kód UT WoS článku

000608255900011

EID výsledku v databázi Scopus

2-s2.0-85097896594