Multilobed Magnetic Liposomes Enable Remotely Controlled Collection, Transport, and Delivery of Membrane-Soluble Cargos to Vesicles and Cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922874" target="_blank" >RIV/60461373:22340/21:43922874 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1021/acsabm.1c00106" target="_blank" >https://doi.org/10.1021/acsabm.1c00106</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsabm.1c00106" target="_blank" >10.1021/acsabm.1c00106</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multilobed Magnetic Liposomes Enable Remotely Controlled Collection, Transport, and Delivery of Membrane-Soluble Cargos to Vesicles and Cells

Popis výsledku v původním jazyce

Lipid bilayers are the basic structural components of all living systems, forming the membranes of cells, sub-cellular organelles, and extracellular vesicles. A class of man-made lipidic vesicles called multilobed magnetic liposomes (MMLs) is reported in this work; these MMLs possess a previously unattained combination of features owing to their unique multilobe structure and composition. MMLs consist of a central cluster of lipid-coated magnetic iron oxide nanoparticles that lend them a magnetophoretic velocity comparable to the most efficient living microswimmers. Multiple liposome-like lobes protrude from the central region; these can incorporate both water-soluble and lipid-soluble molecular payloads at high carrying capacity and exchange the incorporated substances with the membranes of both artificial and live cells by the contact diffusion mechanism. The size of MMLs is controllable in the range of 200-800 nm. Their functionality is demonstrated by completing a model mission where MMLs are remotely controlled to collect, transport, and deliver a cargo to live cells. © 2021 American Chemical Society.

Název v anglickém jazyce

Multilobed Magnetic Liposomes Enable Remotely Controlled Collection, Transport, and Delivery of Membrane-Soluble Cargos to Vesicles and Cells

Popis výsledku anglicky

Lipid bilayers are the basic structural components of all living systems, forming the membranes of cells, sub-cellular organelles, and extracellular vesicles. A class of man-made lipidic vesicles called multilobed magnetic liposomes (MMLs) is reported in this work; these MMLs possess a previously unattained combination of features owing to their unique multilobe structure and composition. MMLs consist of a central cluster of lipid-coated magnetic iron oxide nanoparticles that lend them a magnetophoretic velocity comparable to the most efficient living microswimmers. Multiple liposome-like lobes protrude from the central region; these can incorporate both water-soluble and lipid-soluble molecular payloads at high carrying capacity and exchange the incorporated substances with the membranes of both artificial and live cells by the contact diffusion mechanism. The size of MMLs is controllable in the range of 200-800 nm. Their functionality is demonstrated by completing a model mission where MMLs are remotely controlled to collect, transport, and deliver a cargo to live cells. © 2021 American Chemical Society.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/GA18-14466S" target="_blank" >GA18-14466S: Intensifikace reakčně-difusních procesů magnetickým nanomícháním</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Applied Bio Materials

ISSN

2576-6422

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

4833-4840

Kód UT WoS článku

000664594300015

EID výsledku v databázi Scopus

2-s2.0-85103478597