Novel method for determination of methoxphenidine and its main metabolite in biological samples

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43924053" target="_blank" >RIV/60461373:22340/22:43924053 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22810/22:43924053

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S2352007822003742" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S2352007822003742</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.toxac.2022.06.302" target="_blank" >10.1016/j.toxac.2022.06.302</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Novel method for determination of methoxphenidine and its main metabolite in biological samples

Popis výsledku v původním jazyce

Methoxphenidine (MXP) is new psychoactive substance belonging to the group of dissociative anesthetics. It appeared on the black market in 2013, and MXP intoxications have been reported with at least three deaths since then. To understanding the mechanism of toxicity and effects of MXP, it is important to know its pharmacological properties (e.g. toxicity, activity on receptors and ADME) and metabolism which may be further exploited to study its mechanism of action in vivo. Metabolism of such compound may be useful not only in toxicological screenings, but together with pharmacokinetic and pharmacodynamic data it enhances the knowledge how these substances may affect the living organism. It is still very little information on the MXP and a method for analysis of biological samples (e.g. brain, liver, lungs and serum) remain to be developed.

Název v anglickém jazyce

Novel method for determination of methoxphenidine and its main metabolite in biological samples

Popis výsledku anglicky

Methoxphenidine (MXP) is new psychoactive substance belonging to the group of dissociative anesthetics. It appeared on the black market in 2013, and MXP intoxications have been reported with at least three deaths since then. To understanding the mechanism of toxicity and effects of MXP, it is important to know its pharmacological properties (e.g. toxicity, activity on receptors and ADME) and metabolism which may be further exploited to study its mechanism of action in vivo. Metabolism of such compound may be useful not only in toxicological screenings, but together with pharmacokinetic and pharmacodynamic data it enhances the knowledge how these substances may affect the living organism. It is still very little information on the MXP and a method for analysis of biological samples (e.g. brain, liver, lungs and serum) remain to be developed.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/NU21-04-00307" target="_blank" >NU21-04-00307: Psilocybin versus ketamin – strategie rychlé antidepresivní odpovědi u deprese rezistentní k léčbě</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicologie Analytique et Clinique

ISSN

2352-0078

e-ISSN

2352-0086

Svazek periodika

34

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

2

Strana od-do

"S175"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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