Three Stages of Nascent Protein Translocation Through the Ribosome Exit Tunnel

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F24%3A43930038" target="_blank" >RIV/60461373:22340/24:43930038 - isvavai.cz</a>

Výsledek na webu

<a href="https://wires.onlinelibrary.wiley.com/doi/10.1002/wrna.1873" target="_blank" >https://wires.onlinelibrary.wiley.com/doi/10.1002/wrna.1873</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/wrna.1873" target="_blank" >10.1002/wrna.1873</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Three Stages of Nascent Protein Translocation Through the Ribosome Exit Tunnel

Popis výsledku v původním jazyce

All proteins in living organisms are produced in ribosomes that facilitate the translation of genetic information into a sequence of amino acid residues. During translation, the ribosome undergoes initiation, elongation, termination, and recycling. In fact, peptide bonds are formed only during the elongation phase, which comprises periodic association of transfer RNAs and multiple auxiliary proteins with the ribosome and the addition of an amino acid to the nascent polypeptide one at a time. The protein spends a considerable amount of time attached to the ribosome. Here, we conceptually divide this portion of the protein lifetime into three stages. We define each stage on the basis of the position of the N-terminus of the nascent polypeptide within the ribosome exit tunnel and the context of the catalytic center. We argue that nascent polypeptides experience a variety of forces that determine how they translocate through the tunnel and interact with the tunnel walls. We review current knowledge about nascent polypeptide translocation and identify several white spots in our understanding of the birth of proteins.

Název v anglickém jazyce

Three Stages of Nascent Protein Translocation Through the Ribosome Exit Tunnel

Popis výsledku anglicky

All proteins in living organisms are produced in ribosomes that facilitate the translation of genetic information into a sequence of amino acid residues. During translation, the ribosome undergoes initiation, elongation, termination, and recycling. In fact, peptide bonds are formed only during the elongation phase, which comprises periodic association of transfer RNAs and multiple auxiliary proteins with the ribosome and the addition of an amino acid to the nascent polypeptide one at a time. The protein spends a considerable amount of time attached to the ribosome. Here, we conceptually divide this portion of the protein lifetime into three stages. We define each stage on the basis of the position of the N-terminus of the nascent polypeptide within the ribosome exit tunnel and the context of the catalytic center. We argue that nascent polypeptides experience a variety of forces that determine how they translocate through the tunnel and interact with the tunnel walls. We review current knowledge about nascent polypeptide translocation and identify several white spots in our understanding of the birth of proteins.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA23-05557S" target="_blank" >GA23-05557S: Vstříc atomárnímu pochopení prvních okamžiků života proteinu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Wiley Interdisciplinary Reviews-RNA

ISSN

1757-7004

e-ISSN

1757-7012

Svazek periodika

15

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

"e1873"

Kód UT WoS článku

001368129500001

EID výsledku v databázi Scopus

2-s2.0-85208491593