Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F09%3A%230000057" target="_blank" >RIV/61383082:_____/09:#0000057 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/10:6937 RIV/00064165:_____/10:6937

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6)

Popis výsledku v původním jazyce

Hip trauma and surgery are associated with systemic inflammatory reaction. However, little evidence exists about the role of IL-6. In order to assess the inflammatory response, we evaluated white blood cell (WBC) count, C-reactive protein (CRP) and IL-6dynamics in sequential pre- and postsurgical samples collected from 125 elderly patients (mean age 78 +- 9 years) undergoing osteosynthesis (OS) for extracapsular hip fractures (n = 69), hemiarthroplasty (HA) or urgent total hip arthroplasty for intracapsular fractures (UA) (n = 35), and elective total hip arthroplasty for osteoarthrosis (OA) (n = 21). Both preoperative CRP and IL-6 levels were higher in patients with intracapsular fractures. IL-6 levels reached peak values immediately after the surgery, while CRP peak levels were reached 48 h after the surgery. The overall inflammatory reaction was more intense in HA patients compared to the other subgroups.

Název v anglickém jazyce

Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6)

Popis výsledku anglicky

Hip trauma and surgery are associated with systemic inflammatory reaction. However, little evidence exists about the role of IL-6. In order to assess the inflammatory response, we evaluated white blood cell (WBC) count, C-reactive protein (CRP) and IL-6dynamics in sequential pre- and postsurgical samples collected from 125 elderly patients (mean age 78 +- 9 years) undergoing osteosynthesis (OS) for extracapsular hip fractures (n = 69), hemiarthroplasty (HA) or urgent total hip arthroplasty for intracapsular fractures (UA) (n = 35), and elective total hip arthroplasty for osteoarthrosis (OA) (n = 21). Both preoperative CRP and IL-6 levels were higher in patients with intracapsular fractures. IL-6 levels reached peak values immediately after the surgery, while CRP peak levels were reached 48 h after the surgery. The overall inflammatory reaction was more intense in HA patients compared to the other subgroups.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR8830" target="_blank" >NR8830: Akutní stavy v gerontochirurgii</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Gerontology and Geriatries

ISSN

0167-4943

e-ISSN

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Svazek periodika

2009

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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