Prognostic importance of cell cycle regulators Cyclin D1 (CCND1) and cyclin-dependent kinase inhibitor 1B (CDKN1B/p27) in sporadic gastric cancers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F16%3A00000156" target="_blank" >RIV/61383082:_____/16:00000156 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00092162 RIV/00216208:11110/16:10328349 RIV/00216208:11130/16:10328349

Výsledek na webu

<a href="https://www.hindawi.com/journals/grp/2016/9408190/" target="_blank" >https://www.hindawi.com/journals/grp/2016/9408190/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2016/9408190" target="_blank" >10.1155/2016/9408190</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic importance of cell cycle regulators Cyclin D1 (CCND1) and cyclin-dependent kinase inhibitor 1B (CDKN1B/p27) in sporadic gastric cancers

Popis výsledku v původním jazyce

Background. Gastric cancer is known for a notable variety in the course of the disease. Clinical factors, such as tumor stage, grade, and localization, are key in patient survival. It is expected that molecular factors such as somatic mutations and gene amplifications are also underlying tumor biological behavior and may serve as factors for prognosis estimation. Aim. The purpose of this study was to examine gene amplifications from a panel of genes to uncover potential prognostic marker candidates. Methods. A panel of gene amplifications including 71 genes was tested by multiplex ligation-dependent probe amplification (MLPA) technique in 76 gastric cancer samples from a Caucasian population. The correlation of gene amplification status with patient survival was determined by the Kaplan-Meier method. Results. The amplification of two cell cycle regulators, CCND1 and CDKN1B, was identified to have a negative prognostic role. The medial survival of patients with gastric cancer displaying amplification compared to patients without amplification was 192 versus 725 days for CCND1 (P = 0.0012) and 165 versus 611 days for CDKN1B (P = 0.0098). Conclusion. Gene amplifications of CCND1 and CDKN1B are potential candidates to serve as prognostic markers for the stratification of patients based on the estimate of survival in the management of gastric cancer patients.

Název v anglickém jazyce

Prognostic importance of cell cycle regulators Cyclin D1 (CCND1) and cyclin-dependent kinase inhibitor 1B (CDKN1B/p27) in sporadic gastric cancers

Popis výsledku anglicky

Background. Gastric cancer is known for a notable variety in the course of the disease. Clinical factors, such as tumor stage, grade, and localization, are key in patient survival. It is expected that molecular factors such as somatic mutations and gene amplifications are also underlying tumor biological behavior and may serve as factors for prognosis estimation. Aim. The purpose of this study was to examine gene amplifications from a panel of genes to uncover potential prognostic marker candidates. Methods. A panel of gene amplifications including 71 genes was tested by multiplex ligation-dependent probe amplification (MLPA) technique in 76 gastric cancer samples from a Caucasian population. The correlation of gene amplification status with patient survival was determined by the Kaplan-Meier method. Results. The amplification of two cell cycle regulators, CCND1 and CDKN1B, was identified to have a negative prognostic role. The medial survival of patients with gastric cancer displaying amplification compared to patients without amplification was 192 versus 725 days for CCND1 (P = 0.0012) and 165 versus 611 days for CDKN1B (P = 0.0098). Conclusion. Gene amplifications of CCND1 and CDKN1B are potential candidates to serve as prognostic markers for the stratification of patients based on the estimate of survival in the management of gastric cancer patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

GASTROENTEROLOGY RESEARCH AND PRACTICE

ISSN

1687-6121

e-ISSN

—

Svazek periodika

vol. 2016

Číslo periodika v rámci svazku

2016

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

000385749600001

EID výsledku v databázi Scopus

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