Analgesic-muscle relaxant infusion in back pain therapy – technological and clinical aspects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F21%3A00001144" target="_blank" >RIV/61383082:_____/21:00001144 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.medvik.cz/bmc/view.do?gid=1742362" target="_blank" >https://www.medvik.cz/bmc/view.do?gid=1742362</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccsnn2021465" target="_blank" >10.48095/cccsnn2021465</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analgesic-muscle relaxant infusion in back pain therapy – technological and clinical aspects

Popis výsledku v původním jazyce

Aim: The aim was to clarify the constituents and the method of administration of analgesic-muscle relaxant infusions (AMIs) routinely used in clinical practice, to rationalise individual components in AMIs, and to evaluate the compatibility and stability of the most often used AMI components. Methods: In the form of a questionnaire survey, 15 randomly selected clinical departments were contacted to obtain an overview of the spectrum of AMIs used in the Czech Republic. The rationality of the composition of AMIs was evaluated based on an assessment of the pharmacological and pharmaceutical properties of the drugs and the evidence for their use in back pain therapy. Furthermore, a compatibility and stability study of the two most often used AMIs (mixture No. 1: trimecaine, metamizole, guaifenesin; mixture No. 2: trimecaine, metamizole, magnesium sulfate) was conducted. Results: A large number of diff erent combinations of drugs was found to be used, most often from the group of analgesics, muscle relaxants, corticosteroids, and local anaesthetics. The composition of AMIs proved not to be always completely rational, both from a pharmacotherapeutic (effi cacy, safety, evidence) and technological (compatibility, stability) point of view. The performed technological study then proved the compatibility and stability of the two most frequently used mixtures. Conclusions: The established use of AMIs has a number of signifi cant shortcomings. Therefore, in most cases and for a variety of reasons, oral administration of drugs seems to be more appropriate for the treatment of back pain. Intravenous therapy could thus be reserved for specific situations.

Název v anglickém jazyce

Analgesic-muscle relaxant infusion in back pain therapy – technological and clinical aspects

Popis výsledku anglicky

Aim: The aim was to clarify the constituents and the method of administration of analgesic-muscle relaxant infusions (AMIs) routinely used in clinical practice, to rationalise individual components in AMIs, and to evaluate the compatibility and stability of the most often used AMI components. Methods: In the form of a questionnaire survey, 15 randomly selected clinical departments were contacted to obtain an overview of the spectrum of AMIs used in the Czech Republic. The rationality of the composition of AMIs was evaluated based on an assessment of the pharmacological and pharmaceutical properties of the drugs and the evidence for their use in back pain therapy. Furthermore, a compatibility and stability study of the two most often used AMIs (mixture No. 1: trimecaine, metamizole, guaifenesin; mixture No. 2: trimecaine, metamizole, magnesium sulfate) was conducted. Results: A large number of diff erent combinations of drugs was found to be used, most often from the group of analgesics, muscle relaxants, corticosteroids, and local anaesthetics. The composition of AMIs proved not to be always completely rational, both from a pharmacotherapeutic (effi cacy, safety, evidence) and technological (compatibility, stability) point of view. The performed technological study then proved the compatibility and stability of the two most frequently used mixtures. Conclusions: The established use of AMIs has a number of signifi cant shortcomings. Therefore, in most cases and for a variety of reasons, oral administration of drugs seems to be more appropriate for the treatment of back pain. Intravenous therapy could thus be reserved for specific situations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

ISSN

1942-0900

e-ISSN

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Svazek periodika

2021

Číslo periodika v rámci svazku

Oct 4 2021

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

000762595600003

EID výsledku v databázi Scopus

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