Survival and predictive factors of clinical outcome in patients with severe acquired brain injury.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F24%3A00001372" target="_blank" >RIV/61383082:_____/24:00001372 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/24:10481410 RIV/00216208:11130/24:10481410 RIV/00064203:_____/24:10481410

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/38888736/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/38888736/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S1973-9087.24.08430-2" target="_blank" >10.23736/S1973-9087.24.08430-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Survival and predictive factors of clinical outcome in patients with severe acquired brain injury.

Popis výsledku v původním jazyce

Despite the many tools available to modern medicine, predicting the neurological and functional status of patients after severe brain injury remains difficult. AIM: This analysis evaluates the outcomes of patients with the most severe degree of cerebral function impairment. DESIGN: Retrospective cohort study. SETTING: Patients hospitalized in the long-term Intensive Care Unit (ICU) department in the Military University Hospital in Prague between 2015-2022. POPULATION: We analyzed patients with severe acquired brain damage from five distinct etiologies whose initial Glasgow Coma Scale (GCS) score was eight or less upon admission to ICU due to neurological damage. METHODS: Several parameters refiecting the patients' clinical status were evaluated. Overall survival after discharge from the ICU was calculated according to the Kaplan-Meier model with comparison between traumatic (TR) and non-traumatic (non-TR) etiologies. RESULTS: The analyzed cohort of 221 patients consisted of 116 patients of TR and 105 of non-TR etiology. There was no significant difference in overall survival between TR and non-TR groups. The length of hospitalization in the ICU was similar in both groups with a median of 94 days. The majority of patients had an improvement of GCS during the hospitalization with a median improvement of five points. GCS improvement occurred in the vast majority of patients regardless of TR or non-TR etiology. CONCLUSIONS: We did not observe a statistically significant difference in mortality or log -term neurological status between patients with severe brain injury of traumatic or non-traumatic etiology for the duration of our follow up. The majority of patients had improved GCS, were successfully decannulated, but remained disabled with severe limitations of functional independence. CLINICAL REHABILITATION IMPACT: The return of the patient to normal life is a rehabilitation challenge, regardless of the etiology of brain injury, and is extremely infiuenced by the level of development of neurorehabilitation programs in individual institutions, the severity of brain injury, and the individual motivation of the patient.

Název v anglickém jazyce

Survival and predictive factors of clinical outcome in patients with severe acquired brain injury.

Popis výsledku anglicky

Despite the many tools available to modern medicine, predicting the neurological and functional status of patients after severe brain injury remains difficult. AIM: This analysis evaluates the outcomes of patients with the most severe degree of cerebral function impairment. DESIGN: Retrospective cohort study. SETTING: Patients hospitalized in the long-term Intensive Care Unit (ICU) department in the Military University Hospital in Prague between 2015-2022. POPULATION: We analyzed patients with severe acquired brain damage from five distinct etiologies whose initial Glasgow Coma Scale (GCS) score was eight or less upon admission to ICU due to neurological damage. METHODS: Several parameters refiecting the patients' clinical status were evaluated. Overall survival after discharge from the ICU was calculated according to the Kaplan-Meier model with comparison between traumatic (TR) and non-traumatic (non-TR) etiologies. RESULTS: The analyzed cohort of 221 patients consisted of 116 patients of TR and 105 of non-TR etiology. There was no significant difference in overall survival between TR and non-TR groups. The length of hospitalization in the ICU was similar in both groups with a median of 94 days. The majority of patients had an improvement of GCS during the hospitalization with a median improvement of five points. GCS improvement occurred in the vast majority of patients regardless of TR or non-TR etiology. CONCLUSIONS: We did not observe a statistically significant difference in mortality or log -term neurological status between patients with severe brain injury of traumatic or non-traumatic etiology for the duration of our follow up. The majority of patients had improved GCS, were successfully decannulated, but remained disabled with severe limitations of functional independence. CLINICAL REHABILITATION IMPACT: The return of the patient to normal life is a rehabilitation challenge, regardless of the etiology of brain injury, and is extremely infiuenced by the level of development of neurorehabilitation programs in individual institutions, the severity of brain injury, and the individual motivation of the patient.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30226 - Rheumatology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Physical and Rehabilitation Medicine

ISSN

1973-9087

e-ISSN

—

Svazek periodika

60

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

7

Strana od-do

597-603

Kód UT WoS článku

001249469900001

EID výsledku v databázi Scopus

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