Vancomycin loading dose individualization in a population of obese patients undergoing haemodialysis based on population pharmacokinetic model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F24%3A00001375" target="_blank" >RIV/61383082:_____/24:00001375 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/38887026/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/38887026/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/1120009X.2024.2367937" target="_blank" >10.1080/1120009X.2024.2367937</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vancomycin loading dose individualization in a population of obese patients undergoing haemodialysis based on population pharmacokinetic model

Popis výsledku v původním jazyce

This study aimed to develop a vancomycin population pharmacokinetic model in obese adult patients treated with intermittent haemodialysis and propose a model-based loading dose strategy ensuring attainment of newly recommended AUC-based PK/PD target. Retrospective cross-sectional analysis was performed among obese haemodialysis dependent adult patients treated with intravenous vancomycin. A pharmacokinetic population model was developed using a nonlinear mixed-effects modelling approach and Monte Carlo simulations were used to identify the optimal loading dose for PK/PD target attainment during the first 48 h of treatment. Therapeutic drug monitoring data from 27 patients with a BMI of 30.2–52.9 kg/m2 were analysed. Among all tested variables, only LBM as a covariate of vancomycin Vd significantly improved the model, while vancomycin CL did not correlate with any of the tested variables. The median (IQR) value from the conditional mean of individual estimates of Vd and CL was 68.4 (56.6–84.2) L and 0.86 (0.79–0.90) L/h, respectively. To ensure optimal vancomycin exposure during the first 48 h of therapy, the vancomycin loading dose of 1500, 1750, 2000, 2250, 2500 and 2750 mg should be administered to obese patients with a lean body mass of ˂50, 50–60, 60–70, 70–80, 80–85 and >85 kg, respectively.

Název v anglickém jazyce

Vancomycin loading dose individualization in a population of obese patients undergoing haemodialysis based on population pharmacokinetic model

Popis výsledku anglicky

This study aimed to develop a vancomycin population pharmacokinetic model in obese adult patients treated with intermittent haemodialysis and propose a model-based loading dose strategy ensuring attainment of newly recommended AUC-based PK/PD target. Retrospective cross-sectional analysis was performed among obese haemodialysis dependent adult patients treated with intravenous vancomycin. A pharmacokinetic population model was developed using a nonlinear mixed-effects modelling approach and Monte Carlo simulations were used to identify the optimal loading dose for PK/PD target attainment during the first 48 h of treatment. Therapeutic drug monitoring data from 27 patients with a BMI of 30.2–52.9 kg/m2 were analysed. Among all tested variables, only LBM as a covariate of vancomycin Vd significantly improved the model, while vancomycin CL did not correlate with any of the tested variables. The median (IQR) value from the conditional mean of individual estimates of Vd and CL was 68.4 (56.6–84.2) L and 0.86 (0.79–0.90) L/h, respectively. To ensure optimal vancomycin exposure during the first 48 h of therapy, the vancomycin loading dose of 1500, 1750, 2000, 2250, 2500 and 2750 mg should be administered to obese patients with a lean body mass of ˂50, 50–60, 60–70, 70–80, 80–85 and >85 kg, respectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of chemotherapy

ISSN

1120-009X

e-ISSN

—

Svazek periodika

2024

Číslo periodika v rámci svazku

Jun 17

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

001250717600001

EID výsledku v databázi Scopus

2-s2.0-85196285368