MRI-and CT-derived carotid plaque characteristics and stroke: Insights from the ANTIQUE study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F25%3A00001521" target="_blank" >RIV/61383082:_____/25:00001521 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/25:A2603ATX RIV/00216208:11110/25:10489588 RIV/00216208:11130/25:10489588 RIV/00216208:11150/25:10489588 a 4 dalších

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/39743911/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/39743911/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33963/v.phj.103740" target="_blank" >10.33963/v.phj.103740</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MRI-and CT-derived carotid plaque characteristics and stroke: Insights from the ANTIQUE study

Popis výsledku v původním jazyce

Background: Carotid plaque composition plays a key role in plaque stability and patient risk stratification. Of unstable plaque features, intraplaque hemorrhage (IPH) is considered the main risk factor for stroke development. Aims: We aimed to assess an association between the presence of IPH and other plaque characteristics detectable by computed tomography (CT) or magnetic resonance imaging (MRI) and stroke. Material and methods: Of all consecutive patients from the ANTIQUE study, 132 (91 males; aged 70.0 [8.6] years) with 59 symptomatic and 157 asymptomatic stable carotid plaques were included in the retrospective analysis of prospectively collected data. Plaques in the vascular territory of ischemic stroke within 90 days were classified as symptomatic and were diagnosed by CT and MRI after symptoms occurred. Plaques without progression and clinical infarction were classified as asymptomatic stable. Univariate and multivariate logistic regression analyses were performed to identify risk factors. Results: The presence, age, location, and volume of IPH were not related to stroke risk (P >0.05). Patients with symptomatic plaque were more likely to consume alcohol (P= 0.005), had more severe stenosis (CT median: 80% vs. 72%; P = 0.005; MRI median: 79% vs. 72%; P = 0.01), lower American Heart Association grade (P= 0.03), and more frequent lipid plaque (89.8% vs. 76.4%; P= 0.04) compared to patients with asymptomatic stable plaques. Stenosis severity (odds ratio [OR], 1.037; 95% CI, 1.015–1.059) and additionally alcohol consumption (OR, 3.571; 95% CI, 1.694–7.527) were found to be the only significant predictors of a recent stroke. Conclusions: In this cohort, no IPH or other plaque characteristics were associated with stroke risk. The degree of stenosis and alcohol consumption were the only factors associated with ipsilateral stroke. Larger prospective studies considering plaque characteristics are needed.

Název v anglickém jazyce

MRI-and CT-derived carotid plaque characteristics and stroke: Insights from the ANTIQUE study

Popis výsledku anglicky

Background: Carotid plaque composition plays a key role in plaque stability and patient risk stratification. Of unstable plaque features, intraplaque hemorrhage (IPH) is considered the main risk factor for stroke development. Aims: We aimed to assess an association between the presence of IPH and other plaque characteristics detectable by computed tomography (CT) or magnetic resonance imaging (MRI) and stroke. Material and methods: Of all consecutive patients from the ANTIQUE study, 132 (91 males; aged 70.0 [8.6] years) with 59 symptomatic and 157 asymptomatic stable carotid plaques were included in the retrospective analysis of prospectively collected data. Plaques in the vascular territory of ischemic stroke within 90 days were classified as symptomatic and were diagnosed by CT and MRI after symptoms occurred. Plaques without progression and clinical infarction were classified as asymptomatic stable. Univariate and multivariate logistic regression analyses were performed to identify risk factors. Results: The presence, age, location, and volume of IPH were not related to stroke risk (P >0.05). Patients with symptomatic plaque were more likely to consume alcohol (P= 0.005), had more severe stenosis (CT median: 80% vs. 72%; P = 0.005; MRI median: 79% vs. 72%; P = 0.01), lower American Heart Association grade (P= 0.03), and more frequent lipid plaque (89.8% vs. 76.4%; P= 0.04) compared to patients with asymptomatic stable plaques. Stenosis severity (odds ratio [OR], 1.037; 95% CI, 1.015–1.059) and additionally alcohol consumption (OR, 3.571; 95% CI, 1.694–7.527) were found to be the only significant predictors of a recent stroke. Conclusions: In this cohort, no IPH or other plaque characteristics were associated with stroke risk. The degree of stenosis and alcohol consumption were the only factors associated with ipsilateral stroke. Larger prospective studies considering plaque characteristics are needed.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polish Heart Journal-Kardiologia Polska

ISSN

0022-9032

e-ISSN

—

Svazek periodika

83

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

10

Strana od-do

277 - 286

Kód UT WoS článku

001464158100005

EID výsledku v databázi Scopus

2-s2.0-105001925168