Hydratace lipidů: Hydrofobní CH části molekul se účastní vázání vody

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F04%3A00101131" target="_blank" >RIV/61388955:_____/04:00101131 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lipid Hydration: Headgroup CH Moieties Are Involved in Water Binding

Popis výsledku v původním jazyce

To explore the interaction potential of phospholipids, we have studied the hydration of diacyl phosphatidylcholine (PC) and methylphosphocholine (MePC), a pertinent model compound, by ir spectroscopy. Related ab initio Hartree-Fock calculations were performed for MePC Water is considered ideal as a relevant probe molecule. Spectroscopic data for MePC reveal a strong influence of bound hydration water not only on the phosphate groups but also onto the putatively apolar CHn groups. The same could be demonstrated for deuterated dimyristoyl PC taken as a "complete" lipid molecule: both headgroup methyl and methylene moieties art gradually, but remarkably affected by hydration, as evidenced by strong wavenumber upshifts of C-H stretching vibration hands. These findings may originate in directed interactions of the CHn groups with bound water molecules, but hydration-driven conformational changes of PC headgroups could also occur.

Název v anglickém jazyce

Lipid Hydration: Headgroup CH Moieties Are Involved in Water Binding

Popis výsledku anglicky

To explore the interaction potential of phospholipids, we have studied the hydration of diacyl phosphatidylcholine (PC) and methylphosphocholine (MePC), a pertinent model compound, by ir spectroscopy. Related ab initio Hartree-Fock calculations were performed for MePC Water is considered ideal as a relevant probe molecule. Spectroscopic data for MePC reveal a strong influence of bound hydration water not only on the phosphate groups but also onto the putatively apolar CHn groups. The same could be demonstrated for deuterated dimyristoyl PC taken as a "complete" lipid molecule: both headgroup methyl and methylene moieties art gradually, but remarkably affected by hydration, as evidenced by strong wavenumber upshifts of C-H stretching vibration hands. These findings may originate in directed interactions of the CHn groups with bound water molecules, but hydration-driven conformational changes of PC headgroups could also occur.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/IAA4040904" target="_blank" >IAA4040904: Povrchy potenciální a volné energie nerigidních systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biopolymers

ISSN

0006-3525

e-ISSN

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Svazek periodika

74

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

27-31

Kód UT WoS článku

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EID výsledku v databázi Scopus

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