Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F10%3A00335375" target="_blank" >RIV/61388955:_____/10:00335375 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water

Popis výsledku v původním jazyce

Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN NO2 + e right arrow over left arrow ETN NO2 wascalculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined.

Název v anglickém jazyce

Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water

Popis výsledku anglicky

Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN NO2 + e right arrow over left arrow ETN NO2 wascalculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP203%2F09%2FP502" target="_blank" >GP203/09/P502: Elektrochemické studium redox reakcí radiosenzibilizátorů, léčiv, které zvyšují účinek záření při ničení rakovinových buněk</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bioelectrochemistry

ISSN

1567-5394

e-ISSN

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Svazek periodika

78

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000277218900004

EID výsledku v databázi Scopus

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