Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F10%3A00346349" target="_blank" >RIV/61388955:_____/10:00346349 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11510/10:10080206

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units

Popis výsledku v původním jazyce

The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B-12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B-12 determined in blood. The changes of folates and vitamin B-12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B-12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes.

Název v anglickém jazyce

Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units

Popis výsledku anglicky

The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B-12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B-12 determined in blood. The changes of folates and vitamin B-12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B-12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/IAA400400806" target="_blank" >IAA400400806: Přenos nabitých a nenabitých částic přes modelové biologické membrány</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

59

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

12

Strana od-do

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Kód UT WoS článku

000280363700016

EID výsledku v databázi Scopus

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