Zeolites Promoting Quinoline Synthesis via Friedlander Reaction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F10%3A00437032" target="_blank" >RIV/61388955:_____/10:00437032 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11244-010-9603-8" target="_blank" >http://dx.doi.org/10.1007/s11244-010-9603-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11244-010-9603-8" target="_blank" >10.1007/s11244-010-9603-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Zeolites Promoting Quinoline Synthesis via Friedlander Reaction

Popis výsledku v původním jazyce

Catalytic performance of zeolites H-BEA, H-MFI, H-FAU and H-MOR, exhibiting textural differences and with different Bronsted and Lewis acid sites concentration, have been studied in the synthesis of quinolines via Friedlander reaction. H-BEA and H-FAU efficiently promoted the condensation of 2-aminoaryl ketones 3 with ethyl acetoacetate (4a) or acetylacetone (4b) under mild reaction conditions, those being the first examples of zeolites as catalysts for this transformation. While H-FAU showed similar catalytic behaviour than that reported for (Al)SBA-15 affording mixtures of quinolines 5 and quinolones 6, H-BEA mainly led to quinolines 5 in almost total selectivity and good yields. However, H-MFI and H-MOR zeolites afforded quinolones 6 as the major reaction product. Methodology reported here was found to be useful for the synthesis of biologically active compounds with excellent yields avoiding unnecessary purifications protocols and tedious work-up procedures.

Název v anglickém jazyce

Zeolites Promoting Quinoline Synthesis via Friedlander Reaction

Popis výsledku anglicky

Catalytic performance of zeolites H-BEA, H-MFI, H-FAU and H-MOR, exhibiting textural differences and with different Bronsted and Lewis acid sites concentration, have been studied in the synthesis of quinolines via Friedlander reaction. H-BEA and H-FAU efficiently promoted the condensation of 2-aminoaryl ketones 3 with ethyl acetoacetate (4a) or acetylacetone (4b) under mild reaction conditions, those being the first examples of zeolites as catalysts for this transformation. While H-FAU showed similar catalytic behaviour than that reported for (Al)SBA-15 affording mixtures of quinolines 5 and quinolones 6, H-BEA mainly led to quinolines 5 in almost total selectivity and good yields. However, H-MFI and H-MOR zeolites afforded quinolones 6 as the major reaction product. Methodology reported here was found to be useful for the synthesis of biologically active compounds with excellent yields avoiding unnecessary purifications protocols and tedious work-up procedures.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GD203%2F08%2FH032" target="_blank" >GD203/08/H032: Speciální katalytické procesy a materiály</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Topics in Catalysis

ISSN

1022-5528

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

19-20

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

1430-1437

Kód UT WoS článku

000283584800019

EID výsledku v databázi Scopus

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