An investigation of suitable bag materials for the collection and storage of breath samples containing hydrogen cyanide

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F12%3A00384158" target="_blank" >RIV/61388955:_____/12:00384158 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1088/1752-7155/6/3/036004" target="_blank" >http://dx.doi.org/10.1088/1752-7155/6/3/036004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1752-7155/6/3/036004" target="_blank" >10.1088/1752-7155/6/3/036004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An investigation of suitable bag materials for the collection and storage of breath samples containing hydrogen cyanide

Popis výsledku v původním jazyce

The SPACE study will assess exhaled breath hydrogen cyanide (HCN) concentrations as a marker of Pseudomonas aeruginosa (PA) infection in 240 children with cystic fibrosis (CF). It will use off-line selected ion flow tube mass spectrometry (SIFT-MS) analysis and so we needed to investigate which breath sampling bag material to use, the maximum storage time before analysis and the benefit of warming the bag samples. We studied 15 children with CF, 8 had chronic PA infection and 7 did not. Each exhaled directly into the instrument (on-line) and also into two 25 mu m thick Nalophan (25N), two 70 mu m Nalophan (70N) and two Tedlar (R) bags. Bags were stored at 20 or 37 degrees C. HCN concentrations were analysed at 1, 6, 24 and 48 h (off-line). Acetone andwater vapour concentrations were also measured in parallel. Correlation between on-line and off-line concentrations measured by SIFT-MS was better for all compounds and bag types at 37 degrees C. The median (IQR) on-line HCN concentration

Název v anglickém jazyce

An investigation of suitable bag materials for the collection and storage of breath samples containing hydrogen cyanide

Popis výsledku anglicky

The SPACE study will assess exhaled breath hydrogen cyanide (HCN) concentrations as a marker of Pseudomonas aeruginosa (PA) infection in 240 children with cystic fibrosis (CF). It will use off-line selected ion flow tube mass spectrometry (SIFT-MS) analysis and so we needed to investigate which breath sampling bag material to use, the maximum storage time before analysis and the benefit of warming the bag samples. We studied 15 children with CF, 8 had chronic PA infection and 7 did not. Each exhaled directly into the instrument (on-line) and also into two 25 mu m thick Nalophan (25N), two 70 mu m Nalophan (70N) and two Tedlar (R) bags. Bags were stored at 20 or 37 degrees C. HCN concentrations were analysed at 1, 6, 24 and 48 h (off-line). Acetone andwater vapour concentrations were also measured in parallel. Correlation between on-line and off-line concentrations measured by SIFT-MS was better for all compounds and bag types at 37 degrees C. The median (IQR) on-line HCN concentration

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Breath Research

ISSN

1752-7155

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000308209100004

EID výsledku v databázi Scopus

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