Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F14%3A00424576" target="_blank" >RIV/61388955:_____/14:00424576 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jorganchem.2013.07.059" target="_blank" >http://dx.doi.org/10.1016/j.jorganchem.2013.07.059</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jorganchem.2013.07.059" target="_blank" >10.1016/j.jorganchem.2013.07.059</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes

Popis výsledku v původním jazyce

The previously known complexes [Ti{(Me2CMe2C)(?5-C5H4)2}Cl2] (1), [Ti{Me2C(?5-C5H4)2}Cl2] (2), [Ti{Me2Si(?5-C5H4)2}Cl2] (4), [Ti{MePhSi(?5-C5H4)2}Cl2] (5) and [Ti{MePhSi(?5-C5Me4)2}Cl2] (6) have been prepared following reported procedures. The novel complex [Ti{MePhC(?5-C5H4)2}Cl2] (3) has been prepared and characterized. The cytotoxic activity of 1-6 has been tested after 72 h on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic activity of complexes 1 and 6 compared to the reference compound ([Ti(?5-C5H5)2}Cl2]). 1 and 6 have also been tested against primary normal mouse keratinocytes and lung fibroblasts. While viability of both type of primary cells was significantly less affected by 1 in comparison to the reference compound [Ti(?5-C5H5)2Cl2], compound 6 was completely nontoxic for nonmalignant cells, indicating a potential selectivity of this compound towards cancer cell lines. In addition CFSE

Název v anglickém jazyce

Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes

Popis výsledku anglicky

The previously known complexes [Ti{(Me2CMe2C)(?5-C5H4)2}Cl2] (1), [Ti{Me2C(?5-C5H4)2}Cl2] (2), [Ti{Me2Si(?5-C5H4)2}Cl2] (4), [Ti{MePhSi(?5-C5H4)2}Cl2] (5) and [Ti{MePhSi(?5-C5Me4)2}Cl2] (6) have been prepared following reported procedures. The novel complex [Ti{MePhC(?5-C5H4)2}Cl2] (3) has been prepared and characterized. The cytotoxic activity of 1-6 has been tested after 72 h on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic activity of complexes 1 and 6 compared to the reference compound ([Ti(?5-C5H5)2}Cl2]). 1 and 6 have also been tested against primary normal mouse keratinocytes and lung fibroblasts. While viability of both type of primary cells was significantly less affected by 1 in comparison to the reference compound [Ti(?5-C5H5)2Cl2], compound 6 was completely nontoxic for nonmalignant cells, indicating a potential selectivity of this compound towards cancer cell lines. In addition CFSE

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP207%2F12%2F2368" target="_blank" >GAP207/12/2368: Metaloceny 4 skupiny: aktivace ligandů pro syntetické a katalytické aplikace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Organometallic Chemistry

ISSN

0022-328X

e-ISSN

—

Svazek periodika

751

Číslo periodika v rámci svazku

FEB 2014

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

361-367

Kód UT WoS článku

000329864700031

EID výsledku v databázi Scopus

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