Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F15%3A00443669" target="_blank" >RIV/61388955:_____/15:00443669 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/rcm.7198" target="_blank" >http://dx.doi.org/10.1002/rcm.7198</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/rcm.7198" target="_blank" >10.1002/rcm.7198</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry

Popis výsledku v původním jazyce

It has been proposed that malondialdehyde (MDA) reflects free oxygen-radical lipid peroxidation and can be useful as a biomarker to track this process. For the analysis of MDA molecules in humid air by selected ion flow tube mass spectrometry (SIFT-MS),the rate coefficients and the ion product distributions for the reactions of the SIFT-MS reagent ions with volatile MDA in the presence of water vapour are required. Methods The SIFT technique has been used to determine the rate coefficients and ion product distributions for the reactions of H3O+, NO+ and O2+ with gas-phase MDA. In support of the SIFT-MS analysis of MDA, solid-phase microextraction, SPME, coupled with gas chromatography/mass spectrometry, GC/MS, has been used to confirm the identification of MDA. Results The primary product ions have been identified for the reactions of H3O+, NO+ and O2+ with MDA and the formation of their hydrates formed in humid samples is described. The following combinations of reagent and the analy

Název v anglickém jazyce

Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry

Popis výsledku anglicky

It has been proposed that malondialdehyde (MDA) reflects free oxygen-radical lipid peroxidation and can be useful as a biomarker to track this process. For the analysis of MDA molecules in humid air by selected ion flow tube mass spectrometry (SIFT-MS),the rate coefficients and the ion product distributions for the reactions of the SIFT-MS reagent ions with volatile MDA in the presence of water vapour are required. Methods The SIFT technique has been used to determine the rate coefficients and ion product distributions for the reactions of H3O+, NO+ and O2+ with gas-phase MDA. In support of the SIFT-MS analysis of MDA, solid-phase microextraction, SPME, coupled with gas chromatography/mass spectrometry, GC/MS, has been used to confirm the identification of MDA. Results The primary product ions have been identified for the reactions of H3O+, NO+ and O2+ with MDA and the formation of their hydrates formed in humid samples is described. The following combinations of reagent and the analy

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GP14-15771P" target="_blank" >GP14-15771P: Kombinace SIFT-MS s elektrochemickými metodami pro studium těkavých metabolitů poškozených bakteriálních a buněčných kultur</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Rapid Communications in Mass Spectrometry

ISSN

0951-4198

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

1069-1079

Kód UT WoS článku

000354566900011

EID výsledku v databázi Scopus

—