Serum calcium and phosphorus concentrations and the outcome of calciphylaxis treatment with sodium thiosulfate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00473736" target="_blank" >RIV/61388955:_____/17:00473736 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10361748 RIV/00064165:_____/17:10361748

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00706-016-1850-3" target="_blank" >http://dx.doi.org/10.1007/s00706-016-1850-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-016-1850-3" target="_blank" >10.1007/s00706-016-1850-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serum calcium and phosphorus concentrations and the outcome of calciphylaxis treatment with sodium thiosulfate

Popis výsledku v původním jazyce

Calciphylaxis is severe condition with 45-55 % mortality occurring in chronic dialysis patients. Sporadically, the disease may develop in the patients with normal renal function, for example, in the presence of chronic renal inflammation. Sodium thiosulfate (STS) therapy is a treatment modality of calciphylaxis, but mechanism of its action is unknown. We report four cases of calciphylaxis treated with STS, illustrating that its therapeutic effect is not associated with decreased serum calcium or phosphorus concentration. Therapy with intravenous STS was safe and led to subjective improvement, due to pain reduction, and lesions healing in three of four patients. In one patient, complications of diabetes and other co-morbidities led to unfavorable outcome. STS can be considered promising drug in the treatment of calciphylaxis.

Název v anglickém jazyce

Serum calcium and phosphorus concentrations and the outcome of calciphylaxis treatment with sodium thiosulfate

Popis výsledku anglicky

Calciphylaxis is severe condition with 45-55 % mortality occurring in chronic dialysis patients. Sporadically, the disease may develop in the patients with normal renal function, for example, in the presence of chronic renal inflammation. Sodium thiosulfate (STS) therapy is a treatment modality of calciphylaxis, but mechanism of its action is unknown. We report four cases of calciphylaxis treated with STS, illustrating that its therapeutic effect is not associated with decreased serum calcium or phosphorus concentration. Therapy with intravenous STS was safe and led to subjective improvement, due to pain reduction, and lesions healing in three of four patients. In one patient, complications of diabetes and other co-morbidities led to unfavorable outcome. STS can be considered promising drug in the treatment of calciphylaxis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte fur Chemie

ISSN

0026-9247

e-ISSN

—

Svazek periodika

148

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

6

Strana od-do

435-440

Kód UT WoS článku

000396528600006

EID výsledku v databázi Scopus

2-s2.0-84992337625