Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00474712" target="_blank" >RIV/61388955:_____/17:00474712 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/17:00474712

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c7cc02208e" target="_blank" >http://dx.doi.org/10.1039/c7cc02208e</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c7cc02208e" target="_blank" >10.1039/c7cc02208e</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes

Popis výsledku v původním jazyce

Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol—a key molecule inducing membrane heterogeneity—affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.n

Název v anglickém jazyce

Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes

Popis výsledku anglicky

Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol—a key molecule inducing membrane heterogeneity—affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Communications

ISSN

1359-7345

e-ISSN

—

Svazek periodika

53

Číslo periodika v rámci svazku

39

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

5380-5383

Kód UT WoS článku

000401118400005

EID výsledku v databázi Scopus

2-s2.0-85021689400