Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00534516" target="_blank" >RIV/61388955:_____/20:00534516 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/20:00354326

Výsledek na webu

<a href="http://hdl.handle.net/11104/0312700" target="_blank" >http://hdl.handle.net/11104/0312700</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsnano.9b04898" target="_blank" >10.1021/acsnano.9b04898</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

Popis výsledku v původním jazyce

Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nano-tubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing ´cold´ isotopically enriched samarium (Sm-152), which can then be activated on demand to their ´hot´ radioactive form (Sm-153) by neutron irradiation. The use of ´cold´ isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the ´hot´ nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.

Název v anglickém jazyce

Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

Popis výsledku anglicky

Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nano-tubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing ´cold´ isotopically enriched samarium (Sm-152), which can then be activated on demand to their ´hot´ radioactive form (Sm-153) by neutron irradiation. The use of ´cold´ isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the ´hot´ nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Nano

ISSN

1936-0851

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

129-141

Kód UT WoS článku

000510531500008

EID výsledku v databázi Scopus

2-s2.0-85076733884