Voltammetry of Several Natural and Synthetic Opioids at a Polarized Ionic Liquid Membrane

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00544237" target="_blank" >RIV/61388955:_____/21:00544237 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/21:73609922

Výsledek na webu

<a href="http://hdl.handle.net/11104/0321267" target="_blank" >http://hdl.handle.net/11104/0321267</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/celc.202100701" target="_blank" >10.1002/celc.202100701</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetry of Several Natural and Synthetic Opioids at a Polarized Ionic Liquid Membrane

Popis výsledku v původním jazyce

Cyclic voltammetry is used to examine the transfer of the protonated forms of several natural and synthetic opioids including fentanyl and its analogs, morphine, heroin and codeine, across the polarized interface between an aqueous electrolyte solution and an ionic liquid (IL) membrane. Besides demonstrating the possibility of an amperometric detection and determination, the voltammetric measurements provide the values of the ion partition coefficients and the standard Gibbs energy of ion transfer, along with the partition coefficients for the neutral opioids, which follow the sequence corresponding to the opioid analgesic potency. A correlation between the partition coefficients for the neutral and protonated opioids points to their common basis, which is the difference between the solvation energies of the partitioned species in water and IL phase. A comparison of the experimental and theoretical values of the standard Gibbs energy of ion transfer suggests that the solvophobic interactions play a key role.

Název v anglickém jazyce

Voltammetry of Several Natural and Synthetic Opioids at a Polarized Ionic Liquid Membrane

Popis výsledku anglicky

Cyclic voltammetry is used to examine the transfer of the protonated forms of several natural and synthetic opioids including fentanyl and its analogs, morphine, heroin and codeine, across the polarized interface between an aqueous electrolyte solution and an ionic liquid (IL) membrane. Besides demonstrating the possibility of an amperometric detection and determination, the voltammetric measurements provide the values of the ion partition coefficients and the standard Gibbs energy of ion transfer, along with the partition coefficients for the neutral opioids, which follow the sequence corresponding to the opioid analgesic potency. A correlation between the partition coefficients for the neutral and protonated opioids points to their common basis, which is the difference between the solvation energies of the partitioned species in water and IL phase. A comparison of the experimental and theoretical values of the standard Gibbs energy of ion transfer suggests that the solvophobic interactions play a key role.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

<a href="/cs/project/GA20-07350S" target="_blank" >GA20-07350S: Elektrochemické a analytické aspekty transportu návykových a psychotropních látek přes modelové biologické bariery</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemElectroChem

ISSN

2196-0216

e-ISSN

2196-0216

Svazek periodika

8

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

2519-2525

Kód UT WoS článku

000674273100017

EID výsledku v databázi Scopus

2-s2.0-85110490589