Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F22%3A00552887" target="_blank" >RIV/61388955:_____/22:00552887 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61389013:_____/22:00552887 RIV/61388963:_____/22:00552363 RIV/00216208:11110/22:10443814 RIV/00216208:11320/22:10443814 RIV/00216208:11310/22:10443814
Výsledek na webu
<a href="https://pubs.acs.org/doi/10.1021/acs.macromol.1c01723" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.macromol.1c01723</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.1c01723" target="_blank" >10.1021/acs.macromol.1c01723</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics
Popis výsledku v původním jazyce
Fluorine-19 magnetic resonance imaging (19F MRI) stands out as a powerful tool for noninvasive diagnostics. In particular, polymer-based 19F MRI tracers offer tunable physicochemical properties, including solubility and thermoresponsiveness, and enhanced 19F MRI performance. However, these tracers do not detectably respond to redox changes or do so in only one redox state, thereby preventing potential applications to reactive oxygen species (ROS) bioimaging. Herein, we report the first amphiphilic redox-responsive, poly(2-oxazoline)-based polymers bearing fluorinated ferrocene moieties. Their hydrophobicity and redox responsiveness were tailored by changing the monomer ratio and substitution pattern of the fluorinated ferrocene units. Converting the diamagnetic fluorinated ferrocene moieties into paramagnetic ferrocenium markedly changed the chemical shift and relaxation times of the 19F nuclei distinguishable by 19F MRI. In turn, the statistical–diblock copolymers formed nanoparticles that disassemble upon oxidation, with no toxicity to cultured cells. Therefore, these polymers may be used to release lipophilic drugs in ROS-rich malignancies.
Název v anglickém jazyce
Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics
Popis výsledku anglicky
Fluorine-19 magnetic resonance imaging (19F MRI) stands out as a powerful tool for noninvasive diagnostics. In particular, polymer-based 19F MRI tracers offer tunable physicochemical properties, including solubility and thermoresponsiveness, and enhanced 19F MRI performance. However, these tracers do not detectably respond to redox changes or do so in only one redox state, thereby preventing potential applications to reactive oxygen species (ROS) bioimaging. Herein, we report the first amphiphilic redox-responsive, poly(2-oxazoline)-based polymers bearing fluorinated ferrocene moieties. Their hydrophobicity and redox responsiveness were tailored by changing the monomer ratio and substitution pattern of the fluorinated ferrocene units. Converting the diamagnetic fluorinated ferrocene moieties into paramagnetic ferrocenium markedly changed the chemical shift and relaxation times of the 19F nuclei distinguishable by 19F MRI. In turn, the statistical–diblock copolymers formed nanoparticles that disassemble upon oxidation, with no toxicity to cultured cells. Therefore, these polymers may be used to release lipophilic drugs in ROS-rich malignancies.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10403 - Physical chemistry
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Macromolecules
ISSN
0024-9297
e-ISSN
1520-5835
Svazek periodika
55
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
14
Strana od-do
658-671
Kód UT WoS článku
000739491900001
EID výsledku v databázi Scopus
2-s2.0-85122812925