Voltammetric study of new psychoactive substance 3-fluorophenmetrazine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F23%3A00557347" target="_blank" >RIV/61388955:_____/23:00557347 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/23:10478183 RIV/00216208:11110/23:10478183

Výsledek na webu

<a href="http://hdl.handle.net/11104/0331384" target="_blank" >http://hdl.handle.net/11104/0331384</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elsa.202100223" target="_blank" >10.1002/elsa.202100223</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetric study of new psychoactive substance 3-fluorophenmetrazine

Popis výsledku v původním jazyce

Electrochemical oxidation of the new psychoactive substance 3-fluorophenmetrazine (FPM) was studied in phosphate buffers by cyclic voltammetry and differential pulse voltammetry (DPV) on a glassy carbon electrode. The redox potential of FPM in buffered solution strongly depends on pH. Cyclic voltammetry behavior shows the partial influence of adsorption on the electrode process not allowing detailed analysis of the individual steps of the reaction scheme, it means the involvement of electron transfer (E) and chemical reaction (C). Nevertheless, the irreversible shape of the cyclic voltammogram is explained by the participation of hydroxylation nucleophilic addition of water (hydroxylation) after two-electron/two-proton oxidation of molecule at the tetrahydro-1,4-oxazine ring. The suggested mechanism leading to hydroxylated derivative 2-(3-fluorophenyl)-3-methyl-5-hydroxymorfolin is supported by the calculated highest occupied molecular orbital spatial distribution and atomic charges calculations for electrochemically formed radical cation. Infrared spectroelectrochemistry performed during oxidation in acetonitrile/water also supported the formation of this product.nThe analytical method of FPM determination on glassy carbon electrode was developed using DPV with an attained limit of detection = 4.7 μmol/L in phosphate buffer of pH 9. The linear range of the calibration curve is from 7.0 to 107.00 μmol/L, correlation coefficient (r) = 0.9988.n

Název v anglickém jazyce

Voltammetric study of new psychoactive substance 3-fluorophenmetrazine

Popis výsledku anglicky

Electrochemical oxidation of the new psychoactive substance 3-fluorophenmetrazine (FPM) was studied in phosphate buffers by cyclic voltammetry and differential pulse voltammetry (DPV) on a glassy carbon electrode. The redox potential of FPM in buffered solution strongly depends on pH. Cyclic voltammetry behavior shows the partial influence of adsorption on the electrode process not allowing detailed analysis of the individual steps of the reaction scheme, it means the involvement of electron transfer (E) and chemical reaction (C). Nevertheless, the irreversible shape of the cyclic voltammogram is explained by the participation of hydroxylation nucleophilic addition of water (hydroxylation) after two-electron/two-proton oxidation of molecule at the tetrahydro-1,4-oxazine ring. The suggested mechanism leading to hydroxylated derivative 2-(3-fluorophenyl)-3-methyl-5-hydroxymorfolin is supported by the calculated highest occupied molecular orbital spatial distribution and atomic charges calculations for electrochemically formed radical cation. Infrared spectroelectrochemistry performed during oxidation in acetonitrile/water also supported the formation of this product.nThe analytical method of FPM determination on glassy carbon electrode was developed using DPV with an attained limit of detection = 4.7 μmol/L in phosphate buffer of pH 9. The linear range of the calibration curve is from 7.0 to 107.00 μmol/L, correlation coefficient (r) = 0.9988.n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electrochemical Science Advances

ISSN

2698-5977

e-ISSN

—

Svazek periodika

3

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

e2100223

Kód UT WoS článku

001134957800003

EID výsledku v databázi Scopus

2-s2.0-85173072555