Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds

Popis výsledku v původním jazyce

The electron transfer reactions play an important role in many natural processes. Reactions such as ndissociation, protonation, and reactions with water and other small molecules often occur in nbiotransformation. The reaction schemes involving these chemical reactions coupled to the nelectron transfer can be determined by cyclic voltammetry. Additionally, in nsitu spectroelectrochemistry can efficiently contribute to the determination of oxidation or nreduction mechanism. This technique provides information about the electroactive chromophore during nthe redox process allowing to identification the first reaction intermediates. The final reaction nproducts were identified by chromatographic techniques. This study represents a key role of TR nspectroelectrochemistry in the determination of reaction intermediates in the case of n1,10- phenanthroline derivative substituted by bioactive phenothiazine unit and ndrug 3- fluorophenmetrazine (2-(3-fluorophenyl)-3-methylmorpholine, 3-FPM). Co pound 3-FPMnhave recently appeared as the new psychoactive substance in the drug market.n

Název v anglickém jazyce

Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds

Popis výsledku anglicky

The electron transfer reactions play an important role in many natural processes. Reactions such as ndissociation, protonation, and reactions with water and other small molecules often occur in nbiotransformation. The reaction schemes involving these chemical reactions coupled to the nelectron transfer can be determined by cyclic voltammetry. Additionally, in nsitu spectroelectrochemistry can efficiently contribute to the determination of oxidation or nreduction mechanism. This technique provides information about the electroactive chromophore during nthe redox process allowing to identification the first reaction intermediates. The final reaction nproducts were identified by chromatographic techniques. This study represents a key role of TR nspectroelectrochemistry in the determination of reaction intermediates in the case of n1,10- phenanthroline derivative substituted by bioactive phenothiazine unit and ndrug 3- fluorophenmetrazine (2-(3-fluorophenyl)-3-methylmorpholine, 3-FPM). Co pound 3-FPMnhave recently appeared as the new psychoactive substance in the drug market.n

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Moderní elektrochemické metody /42./. Sborník přednášek

ISBN

978-80-908947-0-9

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

186-190

Název nakladatele

Best servis

Místo vydání

Ústí nad Labem

Místo konání akce

Jetřichovice

Datum konání akce

22. 5. 2023

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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