Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00582145" target="_blank" >RIV/61388955:_____/24:00582145 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985858:_____/24:00582145 RIV/68378041:_____/24:00582145 RIV/60162694:G44__/25:00562027 RIV/46747885:24210/24:00012577 a 2 dalších

Výsledek na webu

<a href="https://www.futuremedicine.com/doi/10.2217/nnm-2023-0207" target="_blank" >https://www.futuremedicine.com/doi/10.2217/nnm-2023-0207</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/nnm-2023-0207" target="_blank" >10.2217/nnm-2023-0207</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress

Popis výsledku v původním jazyce

Aim: To find a practical biomonitoring method for researchers exposed to nanoparticles causing oxidative stress. Methods: In a continuation of a study in 2016–2018, biological samples (plasma, urine and exhaled breath condensate [EBC]) were collected in 2019–2020 from 43 researchers (13.8 ± 3.0 years of exposure) and 45 controls. Antioxidant status was assessed using glutathione (GSH) and ferric-reducing antioxidant power, while oxidative stress was measured as thiobarbituric acid reactive substances, all using spectrophotometric methods. Researchers’ personal nanoparticle exposure was monitored. Results: Plasma GSH was elevated in researchers both before and after exposure (p < 0.01), postexposure plasma GSH correlated with nanoparticle exposure, and GSH in EBC increased. Conclusion: The results suggest adaptation to chronic exposure to nanoparticles, as monitored by plasma and EBC GSH.

Název v anglickém jazyce

Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress

Popis výsledku anglicky

Aim: To find a practical biomonitoring method for researchers exposed to nanoparticles causing oxidative stress. Methods: In a continuation of a study in 2016–2018, biological samples (plasma, urine and exhaled breath condensate [EBC]) were collected in 2019–2020 from 43 researchers (13.8 ± 3.0 years of exposure) and 45 controls. Antioxidant status was assessed using glutathione (GSH) and ferric-reducing antioxidant power, while oxidative stress was measured as thiobarbituric acid reactive substances, all using spectrophotometric methods. Researchers’ personal nanoparticle exposure was monitored. Results: Plasma GSH was elevated in researchers both before and after exposure (p < 0.01), postexposure plasma GSH correlated with nanoparticle exposure, and GSH in EBC increased. Conclusion: The results suggest adaptation to chronic exposure to nanoparticles, as monitored by plasma and EBC GSH.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GA22-08358S" target="_blank" >GA22-08358S: Změny transkriptomu a integrita genomu u osob akutně a chronicky exponovaných nanočásticím</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanomedicine

ISSN

1743-5889

e-ISSN

1748-6963

Svazek periodika

19

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

185-198

Kód UT WoS článku

001151680900001

EID výsledku v databázi Scopus

2-s2.0-85184288746