Dimetindene-Is the minimum toxic dose for children too strict?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00584870" target="_blank" >RIV/61388955:_____/24:00584870 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/24:10480214 RIV/00064165:_____/24:10480214

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/bcpt.14005" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/bcpt.14005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bcpt.14005" target="_blank" >10.1111/bcpt.14005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dimetindene-Is the minimum toxic dose for children too strict?

Popis výsledku v původním jazyce

Dimetindene is a sedating antihistamine indicated for the symptomatic treatment of allergic conditions. Dimetindene is marketed among others under the trade name Fenistil (oral solution). Toxicity data are limited, and there is no consensus on the dose at which children require hospitalization. Objective is to determine the potentially toxic dose in children. Data in children with age up to 15 years were obtained from hospital discharge reports. Of 139 paediatric hospital discharge reports, 23 cases (16.5%) were excluded because of uncertain ingestion. In 116 children (46 boys and 70 girls, mean age 2 years and 9 months +/- 1 year and 1 month), the majority of children developed no symptoms (87 children, 75%, mean age 3 years +/- 1 year) and the remaining 29 children (25%, mean age 2 years and 11 months +/- 1 year and 3 months) developed only mild and spontaneously resolving symptoms of poisoning after a dose of 0.82 +/- 0.32 mg/kg b.w. (range 0.26-1.82 mg/kg). In 98% of all cases, hospitalized children were observed for a maximum 24 h, and their condition did not require specific treatment. In conclusion, the prognosis for accidental dimetindene poisoning in children appears to be good and the minimum toxic dose has been determined to be 0.5 mg/kg b.w.

Název v anglickém jazyce

Dimetindene-Is the minimum toxic dose for children too strict?

Popis výsledku anglicky

Dimetindene is a sedating antihistamine indicated for the symptomatic treatment of allergic conditions. Dimetindene is marketed among others under the trade name Fenistil (oral solution). Toxicity data are limited, and there is no consensus on the dose at which children require hospitalization. Objective is to determine the potentially toxic dose in children. Data in children with age up to 15 years were obtained from hospital discharge reports. Of 139 paediatric hospital discharge reports, 23 cases (16.5%) were excluded because of uncertain ingestion. In 116 children (46 boys and 70 girls, mean age 2 years and 9 months +/- 1 year and 1 month), the majority of children developed no symptoms (87 children, 75%, mean age 3 years +/- 1 year) and the remaining 29 children (25%, mean age 2 years and 11 months +/- 1 year and 3 months) developed only mild and spontaneously resolving symptoms of poisoning after a dose of 0.82 +/- 0.32 mg/kg b.w. (range 0.26-1.82 mg/kg). In 98% of all cases, hospitalized children were observed for a maximum 24 h, and their condition did not require specific treatment. In conclusion, the prognosis for accidental dimetindene poisoning in children appears to be good and the minimum toxic dose has been determined to be 0.5 mg/kg b.w.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Basic & Clinical Pharmacology & Toxicology

ISSN

1742-7835

e-ISSN

1742-7843

Svazek periodika

134

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

750-755

Kód UT WoS článku

001189182500001

EID výsledku v databázi Scopus

2-s2.0-85189154340