Assessing vitamin E acetate as a proxy for E-cigarette additives in a realistic pulmonary surfactant model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00600120" target="_blank" >RIV/61388955:_____/24:00600120 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/24:00599751

Výsledek na webu

<a href="https://hdl.handle.net/11104/0357479" target="_blank" >https://hdl.handle.net/11104/0357479</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-024-75301-8" target="_blank" >10.1038/s41598-024-75301-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Assessing vitamin E acetate as a proxy for E-cigarette additives in a realistic pulmonary surfactant model

Popis výsledku v původním jazyce

Additives in vaping products, such as flavors, preservatives, or thickening agents, are commonly used to enhance user experience. Among these, Vitamin E acetate (VEA) was initially thought to be harmless but has been implicated as the primary cause of e-cigarette or vaping product use-associated lung injury, a serious lung disease. In our study, VEA serves as a proxy for other e-cigarette additives. To explore its harmful effects, we developed an exposure system to subject a pulmonary surfactant (PSurf) model to VEA-rich vapor. Through detailed analysis and atomic-level simulations, we found that VEA tends to cluster into aggregates on the PSurf surface, inducing deformations and weakening its essential elastic properties, critical for respiratory cycle function. Apart from VEA, our experiments also indicate that propylene glycol and vegetable glycerin, widely used in e-liquid mixtures, or their thermal decomposition products, alter surfactant properties. This research provides molecular-level insights into the detrimental impacts of vaping product additives on lung health.

Název v anglickém jazyce

Assessing vitamin E acetate as a proxy for E-cigarette additives in a realistic pulmonary surfactant model

Popis výsledku anglicky

Additives in vaping products, such as flavors, preservatives, or thickening agents, are commonly used to enhance user experience. Among these, Vitamin E acetate (VEA) was initially thought to be harmless but has been implicated as the primary cause of e-cigarette or vaping product use-associated lung injury, a serious lung disease. In our study, VEA serves as a proxy for other e-cigarette additives. To explore its harmful effects, we developed an exposure system to subject a pulmonary surfactant (PSurf) model to VEA-rich vapor. Through detailed analysis and atomic-level simulations, we found that VEA tends to cluster into aggregates on the PSurf surface, inducing deformations and weakening its essential elastic properties, critical for respiratory cycle function. Apart from VEA, our experiments also indicate that propylene glycol and vegetable glycerin, widely used in e-liquid mixtures, or their thermal decomposition products, alter surfactant properties. This research provides molecular-level insights into the detrimental impacts of vaping product additives on lung health.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GA21-19854S" target="_blank" >GA21-19854S: Lipidové multivrstvy v biologickém kontextu - mikroskopie Langmuirova filmu a simulace molekulové dynamiky</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

23805

Kód UT WoS článku

001336221700034

EID výsledku v databázi Scopus

2-s2.0-85206123002