Extent of Intramolecular p-Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and Several 2-Aminopurine Derivatives of the Antivirally Active Nucleotide Analog 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00385302" target="_blank" >RIV/61388963:_____/12:00385302 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/cbdv.201200022" target="_blank" >http://dx.doi.org/10.1002/cbdv.201200022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cbdv.201200022" target="_blank" >10.1002/cbdv.201200022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Extent of Intramolecular p-Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and Several 2-Aminopurine Derivatives of the Antivirally Active Nucleotide Analog 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)

Popis výsledku v původním jazyce

The acidity constants of twofold protonated, antivirally active, acyclic nucleoside phosphonates (ANPs), 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), 2-amino-9-[2-(phosphonomethoxy)ethyl]purine (PME2AP), 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP), or 2-amino-6-(dimethylamino)-9-[2-(phosphonomethoxy)ethyl]purine (PME(2A6DMAP), as well as the stability constants of the corresponding ternary Cu complexes are compared. The constants for the systems containing PMEDAP and PME(2A6DMAP) have beendetermined now by potentiometric pH titrations in aqueous solution at I=0.1M (NaNO3) and 25 degrees; the corresponding results for the other ANPs were taken from our earlier work. The basicity of the terminal phosphonate group is very similar for all theANP species, whereas the addition of a second amino substituent at the pyrimidine ring of the purine moiety significantly increases the basicity of the N(1) site. Detailed stability-constant comparisons for mixed-ligand Cu(II) complexes

Název v anglickém jazyce

Extent of Intramolecular p-Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and Several 2-Aminopurine Derivatives of the Antivirally Active Nucleotide Analog 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)

Popis výsledku anglicky

The acidity constants of twofold protonated, antivirally active, acyclic nucleoside phosphonates (ANPs), 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), 2-amino-9-[2-(phosphonomethoxy)ethyl]purine (PME2AP), 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP), or 2-amino-6-(dimethylamino)-9-[2-(phosphonomethoxy)ethyl]purine (PME(2A6DMAP), as well as the stability constants of the corresponding ternary Cu complexes are compared. The constants for the systems containing PMEDAP and PME(2A6DMAP) have beendetermined now by potentiometric pH titrations in aqueous solution at I=0.1M (NaNO3) and 25 degrees; the corresponding results for the other ANPs were taken from our earlier work. The basicity of the terminal phosphonate group is very similar for all theANP species, whereas the addition of a second amino substituent at the pyrimidine ring of the purine moiety significantly increases the basicity of the N(1) site. Detailed stability-constant comparisons for mixed-ligand Cu(II) complexes

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/1M0508" target="_blank" >1M0508: Nová antivirotika a antineoplastika</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemistry & Biodiversity

ISSN

1612-1872

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

27

Strana od-do

2008-2034

Kód UT WoS článku

000308715800032

EID výsledku v databázi Scopus

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