Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00397563" target="_blank" >RIV/61388963:_____/13:00397563 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11160/13:10144051
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.tox.2013.07.004" target="_blank" >http://dx.doi.org/10.1016/j.tox.2013.07.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tox.2013.07.004" target="_blank" >10.1016/j.tox.2013.07.004</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates
Popis výsledku v původním jazyce
Acyclic nucleoside phosphonates (ANPs) possess antiviral and antiproliferative activities. This study investigated in vitro relationships between the affinity of several structurally related potent ANPs to selected human transporters and their cytotoxicity. SLC (solute carrier family) transporters (hOAT1, hOCT2, hCNT2, hCNT3) and ABC (ATP-binding cassette) transporters (MDR1, BCRP), which are typically expressed in the kidney, were included in the study. Most of the ANPs studied showed the potency to interact with hOAT1 and GS-9191, a double prodrug of PMEG, displayed an affinity for hOAT1 comparable with that of adefovir and tenofovir. The study documented that among the studied transporters hOAT1 seems to be the decisive determinant for renal handling in most of the tested ANPs. This transporter may also play an important role in the mechanism of their potential cytotoxic effects.
Název v anglickém jazyce
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates
Popis výsledku anglicky
Acyclic nucleoside phosphonates (ANPs) possess antiviral and antiproliferative activities. This study investigated in vitro relationships between the affinity of several structurally related potent ANPs to selected human transporters and their cytotoxicity. SLC (solute carrier family) transporters (hOAT1, hOCT2, hCNT2, hCNT3) and ABC (ATP-binding cassette) transporters (MDR1, BCRP), which are typically expressed in the kidney, were included in the study. Most of the ANPs studied showed the potency to interact with hOAT1 and GS-9191, a double prodrug of PMEG, displayed an affinity for hOAT1 comparable with that of adefovir and tenofovir. The study documented that among the studied transporters hOAT1 seems to be the decisive determinant for renal handling in most of the tested ANPs. This transporter may also play an important role in the mechanism of their potential cytotoxic effects.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT12398" target="_blank" >NT12398: Studium vztahu mezi toxicitou a transportními mechanismy antivirotik</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Toxicology
ISSN
0300-483X
e-ISSN
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Svazek periodika
311
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
IE - Irsko
Počet stran výsledku
12
Strana od-do
135-146
Kód UT WoS článku
000324609200006
EID výsledku v databázi Scopus
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