Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00424054" target="_blank" >RIV/61388963:_____/13:00424054 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2174/22115528112019990009" target="_blank" >http://dx.doi.org/10.2174/22115528112019990009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/22115528112019990009" target="_blank" >10.2174/22115528112019990009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis

Popis výsledku v původním jazyce

Enantiomerically pure product synthesis plays a key role in production of pharmaceuticals. The application of biocatalytic approaches represents a convenient and sustainable way for this purpose. The enormous potential of enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity is on increasing awareness. In particular, lipases show a high versatility to recognize non-natural substrates being successfully applied in regio- and stereoselective biotransformations. The immobilization technology on lipases is not only a requisite for the industrial implementation but it has been a great methodology to alter their catalytic properties to obtain highly enantio- and regiose-lective biocatalysts in the enantioselective synthesis of chiral drugs or drug intermediates. This review focuses on showing some of the latest advances on the use of immobilized lipases on pharmaceutical biotransformations.

Název v anglickém jazyce

Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis

Popis výsledku anglicky

Enantiomerically pure product synthesis plays a key role in production of pharmaceuticals. The application of biocatalytic approaches represents a convenient and sustainable way for this purpose. The enormous potential of enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity is on increasing awareness. In particular, lipases show a high versatility to recognize non-natural substrates being successfully applied in regio- and stereoselective biotransformations. The immobilization technology on lipases is not only a requisite for the industrial implementation but it has been a great methodology to alter their catalytic properties to obtain highly enantio- and regiose-lective biocatalysts in the enantioselective synthesis of chiral drugs or drug intermediates. This review focuses on showing some of the latest advances on the use of immobilized lipases on pharmaceutical biotransformations.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Bioactive Compounds

ISSN

1573-4072

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

24

Strana od-do

113-136

Kód UT WoS článku

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EID výsledku v databázi Scopus

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