Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00430390" target="_blank" >RIV/61388963:_____/14:00430390 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ardp.201300431" target="_blank" >http://dx.doi.org/10.1002/ardp.201300431</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ardp.201300431" target="_blank" >10.1002/ardp.201300431</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position

Popis výsledku v původním jazyce

The synthesis of a novel library of purine derivatives bearing various bicyclic and polycylic substituents at the N-9 position is described. The series includes norbornanes, bicyclo[2.2.2] octanes, and bicyclo[3.2.1] octanes attached at the bridgehead position as well as bicyclo[3.1.1] heptanes, tetrahydro-1-naphthalenes, and adamantanes bonded either directly or via a linear chain to the 6-chloropurine nucleobase. A number of prepared derivatives exerted significant activity against the enterovirus. Despite attempts to correlate the activity against picornaviruses with their phosphatidylinositol 4-kinase KIII beta inhibitory activity, it is clear that the inhibition of this host factor cannot explain the observed antiviral potency.

Název v anglickém jazyce

Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position

Popis výsledku anglicky

The synthesis of a novel library of purine derivatives bearing various bicyclic and polycylic substituents at the N-9 position is described. The series includes norbornanes, bicyclo[2.2.2] octanes, and bicyclo[3.2.1] octanes attached at the bridgehead position as well as bicyclo[3.1.1] heptanes, tetrahydro-1-naphthalenes, and adamantanes bonded either directly or via a linear chain to the 6-chloropurine nucleobase. A number of prepared derivatives exerted significant activity against the enterovirus. Despite attempts to correlate the activity against picornaviruses with their phosphatidylinositol 4-kinase KIII beta inhibitory activity, it is clear that the inhibition of this host factor cannot explain the observed antiviral potency.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP303%2F11%2F1297" target="_blank" >GAP303/11/1297: Mechanismus protivirové a cytostatické aktivity nových karbocyklických analogů nukleosidů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archiv der Pharmazie

ISSN

0365-6233

e-ISSN

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Svazek periodika

347

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

478-485

Kód UT WoS článku

000338940600003

EID výsledku v databázi Scopus

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