The "sweet" side of ion channels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00442803" target="_blank" >RIV/61388963:_____/14:00442803 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/112_2014_20" target="_blank" >http://dx.doi.org/10.1007/112_2014_20</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/112_2014_20" target="_blank" >10.1007/112_2014_20</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The "sweet" side of ion channels

Popis výsledku v původním jazyce

Ion channels play a crucial role in cell functioning, contributing to transmembrane potential and participating in cell signalling and homeostasis. To fulfil highly specialised functions, cells have developed various mechanisms to regulate channel expression and activity at particular subcellular loci, and alteration of ion channel regulation can lead to serious disorders. Glycosylation, one of the most common forms of co- and post-translational protein modification, is rapidly emerging as a fundamentalmechanism not only controlling the proper folding of nascent channels but also their subcellular localisation, gating and function. Moreover, studies on various channel subtypes have revealed that glycosylation represents an important determinant by which other signalling pathways modulate channel activity. The discovery of detailed mechanisms of regulation of ion channels by glycosylation provides new insights in the physiology of ion channels and may allow developing new pharmaceutics

Název v anglickém jazyce

The "sweet" side of ion channels

Popis výsledku anglicky

Ion channels play a crucial role in cell functioning, contributing to transmembrane potential and participating in cell signalling and homeostasis. To fulfil highly specialised functions, cells have developed various mechanisms to regulate channel expression and activity at particular subcellular loci, and alteration of ion channel regulation can lead to serious disorders. Glycosylation, one of the most common forms of co- and post-translational protein modification, is rapidly emerging as a fundamentalmechanism not only controlling the proper folding of nascent channels but also their subcellular localisation, gating and function. Moreover, studies on various channel subtypes have revealed that glycosylation represents an important determinant by which other signalling pathways modulate channel activity. The discovery of detailed mechanisms of regulation of ion channels by glycosylation provides new insights in the physiology of ion channels and may allow developing new pharmaceutics

Druh

C - Kapitola v odborné knize

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Reviews of Physiology, Biochemistry and Pharmacology

ISBN

978-3-319-11920-5

Počet stran výsledku

48

Strana od-do

67-114

Počet stran knihy

139

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

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