Interaction of L-Phenylalanine with a Phospholipid Monolayer at the WaterAir Interface

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00446772" target="_blank" >RIV/61388963:_____/15:00446772 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/15:00446772

Výsledek na webu

<a href="http://dx.doi.org/10.1021/jp508473w" target="_blank" >http://dx.doi.org/10.1021/jp508473w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/jp508473w" target="_blank" >10.1021/jp508473w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interaction of L-Phenylalanine with a Phospholipid Monolayer at the WaterAir Interface

Popis výsledku v původním jazyce

The interaction of L-phenylalanine with a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer at the air-water interface was explored using a combination of experimental techniques and molecular dynamics (MD) simulations. By means of Langmuir trough methods and Brewster angle microscopy, L-phenylalanine was shown to significantly alter the interfacial tension and the surface domain morphology of the DPPC film. In addition, confocal microscopy was used to explore the aggregation state of L-phenylalanine in the bulk aqueous phase. Finally, MD simulations were performed to gain molecular-level information on the interactions of L-phenylalanine and DPPC at the interface. Taken together, these results show that L-phenylalanine intercalates into a DPPC film at the air-water interface, thereby affecting the surface tension, phase morphology, and ordering of the DPPC film. The results are discussed in the context of biological systems and the mechanism of diseases such as phenylketonu

Název v anglickém jazyce

Interaction of L-Phenylalanine with a Phospholipid Monolayer at the WaterAir Interface

Popis výsledku anglicky

The interaction of L-phenylalanine with a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer at the air-water interface was explored using a combination of experimental techniques and molecular dynamics (MD) simulations. By means of Langmuir trough methods and Brewster angle microscopy, L-phenylalanine was shown to significantly alter the interfacial tension and the surface domain morphology of the DPPC film. In addition, confocal microscopy was used to explore the aggregation state of L-phenylalanine in the bulk aqueous phase. Finally, MD simulations were performed to gain molecular-level information on the interactions of L-phenylalanine and DPPC at the interface. Taken together, these results show that L-phenylalanine intercalates into a DPPC film at the air-water interface, thereby affecting the surface tension, phase morphology, and ordering of the DPPC film. The results are discussed in the context of biological systems and the mechanism of diseases such as phenylketonu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-06181S" target="_blank" >GA13-06181S: Výzkum lipidových Langmuirových monovrstev a jejich interakce s atmosférickými oxidanty a polutanty pomocí molekulových simulací</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Physical Chemistry B

ISSN

1520-6106

e-ISSN

—

Svazek periodika

119

Číslo periodika v rámci svazku

29

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

9038-9048

Kód UT WoS článku

000358623900024

EID výsledku v databázi Scopus

2-s2.0-84937840402