Peripheral administration of palmitoylated prolactin-releasing peptide induces Fos expression in hypothalamic neurons involved in energy homeostasis in NMRI male mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00453405" target="_blank" >RIV/61388963:_____/15:00453405 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.brainres.2015.08.042" target="_blank" >http://dx.doi.org/10.1016/j.brainres.2015.08.042</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brainres.2015.08.042" target="_blank" >10.1016/j.brainres.2015.08.042</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Peripheral administration of palmitoylated prolactin-releasing peptide induces Fos expression in hypothalamic neurons involved in energy homeostasis in NMRI male mice

Popis výsledku v původním jazyce

Energy homeostasis is the result of a balance between energy intake and expenditure, and the hypothalamus plays a key role in the regulation of these processes. The hypothalamic prolactin-releasing peptide (PrRP) is involved in food intake regulation andenergy homeostasis, although only its lipidized analogs exert central anorexigenic effects after peripheral administration. The aim of the present study was to delineate the extent of the Fos expression as a marker of neuronal activation within the hypothalamic structures involved in food intake regulation after peripherally administered palmitoylated PrRP31 (palm-PrRP31) and to determine whether the anorexigenic effect of peripherally administered palm-PrRP31 influence the activity of hypocretin (HCRT) and oxytocin (OXY) neurons, i.e., the neuropeptides crucially involved in the regulation of energy homeostasis. The data confirmed an anorexigenic effect of palm-PrRP31 treatment (5 mg/kg, s.c.) in mice. In the palm-PrRP31-treated anima

Název v anglickém jazyce

Peripheral administration of palmitoylated prolactin-releasing peptide induces Fos expression in hypothalamic neurons involved in energy homeostasis in NMRI male mice

Popis výsledku anglicky

Energy homeostasis is the result of a balance between energy intake and expenditure, and the hypothalamus plays a key role in the regulation of these processes. The hypothalamic prolactin-releasing peptide (PrRP) is involved in food intake regulation andenergy homeostasis, although only its lipidized analogs exert central anorexigenic effects after peripheral administration. The aim of the present study was to delineate the extent of the Fos expression as a marker of neuronal activation within the hypothalamic structures involved in food intake regulation after peripherally administered palmitoylated PrRP31 (palm-PrRP31) and to determine whether the anorexigenic effect of peripherally administered palm-PrRP31 influence the activity of hypocretin (HCRT) and oxytocin (OXY) neurons, i.e., the neuropeptides crucially involved in the regulation of energy homeostasis. The data confirmed an anorexigenic effect of palm-PrRP31 treatment (5 mg/kg, s.c.) in mice. In the palm-PrRP31-treated anima

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA15-08679S" target="_blank" >GA15-08679S: Vliv stabilních analogů peptidu uvolňujícího prolaktin na obezitu a hypertenzi v experimentálních modelech</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Research

ISSN

0006-8993

e-ISSN

—

Svazek periodika

1625

Číslo periodika v rámci svazku

Nov 2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

151-158

Kód UT WoS článku

000365052000016

EID výsledku v databázi Scopus

2-s2.0-84948431210