Thienopyrrolo[2, 3-d]pyrimidines, New Tricyclic Nucleobase Analogues: Synthesis and Biological Activities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00493609" target="_blank" >RIV/61388963:_____/18:00493609 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/18:10383273

Výsledek na webu

<a href="http://dx.doi.org/10.1002/slct.201802190" target="_blank" >http://dx.doi.org/10.1002/slct.201802190</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/slct.201802190" target="_blank" >10.1002/slct.201802190</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thienopyrrolo[2, 3-d]pyrimidines, New Tricyclic Nucleobase Analogues: Synthesis and Biological Activities

Popis výsledku v původním jazyce

Three isomeric series of 4-substituted thieno-fused 7-deazapurine nucleobases were synthesized by palladium catalyzed couplings or nucleophilic substitutions from protected key-intermediate 4-chlorothienopyrrolopyrimidines. Most final nucleobases exerted micromolar activity against hepatitis C virus and respiratory syncytial virus, as well as some in vitro cytostatic activities against several cancer and leukemia cell lines. Three new nucleosides derived from 8H-thieno[3',4':4,5]pyrrolo[2,3-d] pyrimidine were also synthesized and were significantly more cytostatic than corresponding nucleobases, with activities in submicromolar range and low toxicity to normal cycling fibroblasts.

Název v anglickém jazyce

Thienopyrrolo[2, 3-d]pyrimidines, New Tricyclic Nucleobase Analogues: Synthesis and Biological Activities

Popis výsledku anglicky

Three isomeric series of 4-substituted thieno-fused 7-deazapurine nucleobases were synthesized by palladium catalyzed couplings or nucleophilic substitutions from protected key-intermediate 4-chlorothienopyrrolopyrimidines. Most final nucleobases exerted micromolar activity against hepatitis C virus and respiratory syncytial virus, as well as some in vitro cytostatic activities against several cancer and leukemia cell lines. Three new nucleosides derived from 8H-thieno[3',4':4,5]pyrrolo[2,3-d] pyrimidine were also synthesized and were significantly more cytostatic than corresponding nucleobases, with activities in submicromolar range and low toxicity to normal cycling fibroblasts.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/GA16-00178S" target="_blank" >GA16-00178S: Nové nukleosidy a nukleotidy odvozené od heteroanelovaných 7-deazapurinů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemistrySelect

ISSN

2365-6549

e-ISSN

—

Svazek periodika

3

Číslo periodika v rámci svazku

31

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

9144-9149

Kód UT WoS článku

000442985800049

EID výsledku v databázi Scopus

2-s2.0-85052606083