Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00495687" target="_blank" >RIV/61388963:_____/18:00495687 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ejoc.201800601" target="_blank" >http://dx.doi.org/10.1002/ejoc.201800601</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ejoc.201800601" target="_blank" >10.1002/ejoc.201800601</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides

Popis výsledku v původním jazyce

Multi-orthogonal scaffolds can be useful for the attachment of several different compounds to the same central skeleton. Such compounds can find applications in the development of protein mimics because of their potential to mimic several distant epitopes in the protein structure. Three new tri-orthogonal variants of a previously reported scaffold have been developed that are suitable for the solid-phase synthesis of three different peptides on the same skeleton. Different chemical moieties were combined for the phased attachment of amino acids to the scaffolds: Fmoc- or Alloc-protected amine, free or TIPS-protected alkyne or azido group. Several model compounds were prepared, characterized, and compared for their suitability as new scaffolds for peptide synthesis. All three scaffolds provided peptides with satisfactory yields and purities, making them suitable for a synthesis of libraries of compounds.

Název v anglickém jazyce

Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides

Popis výsledku anglicky

Multi-orthogonal scaffolds can be useful for the attachment of several different compounds to the same central skeleton. Such compounds can find applications in the development of protein mimics because of their potential to mimic several distant epitopes in the protein structure. Three new tri-orthogonal variants of a previously reported scaffold have been developed that are suitable for the solid-phase synthesis of three different peptides on the same skeleton. Different chemical moieties were combined for the phased attachment of amino acids to the scaffolds: Fmoc- or Alloc-protected amine, free or TIPS-protected alkyne or azido group. Several model compounds were prepared, characterized, and compared for their suitability as new scaffolds for peptide synthesis. All three scaffolds provided peptides with satisfactory yields and purities, making them suitable for a synthesis of libraries of compounds.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Organic Chemistry

ISSN

1434-193X

e-ISSN

—

Svazek periodika

2018

Číslo periodika v rámci svazku

37

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

5180-5192

Kód UT WoS článku

000446662900012

EID výsledku v databázi Scopus

2-s2.0-85050621783