Optical tools for understanding the complexity of beta-cell signalling and insulin release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00498654" target="_blank" >RIV/61388963:_____/18:00498654 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1038/s41574-018-0105-2" target="_blank" >http://dx.doi.org/10.1038/s41574-018-0105-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41574-018-0105-2" target="_blank" >10.1038/s41574-018-0105-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Optical tools for understanding the complexity of beta-cell signalling and insulin release

Popis výsledku v původním jazyce

Following stimulation, pancreatic beta-cells must orchestrate a plethora of signalling events to ensure the appropriate release of insulin and maintenance of normal glucose homeostasis. Failure at any point in this cascade leads to impaired insulin secretion, elevated blood levels of glucose and eventually type 2 diabetes mellitus. Likewise, beta-cell replacement or regeneration strategies for the treatment of both type 1 and type 2 diabetes mellitus might fail if the correct cell signalling phenotype cannot be faithfully recreated. However, current understanding of beta-cell function is complicated because of the highly dynamic nature of their intracellular and intercellular signalling as well as insulin release itself. beta-Cells must precisely integrate multiple signals stemming from multiple cues, often with differing intensities, frequencies and cellular and subcellular localizations, before converging these signals onto insulin exocytosis. In this respect, optical approaches with high resolution in space and time are extremely useful for properly deciphering the complexity of beta-cell signalling. An increased understanding of beta-cell signalling might identify new mechanisms underlying insulin release, with relevance for future drug therapy and de novo stem cell engineering of functional islets.

Název v anglickém jazyce

Optical tools for understanding the complexity of beta-cell signalling and insulin release

Popis výsledku anglicky

Following stimulation, pancreatic beta-cells must orchestrate a plethora of signalling events to ensure the appropriate release of insulin and maintenance of normal glucose homeostasis. Failure at any point in this cascade leads to impaired insulin secretion, elevated blood levels of glucose and eventually type 2 diabetes mellitus. Likewise, beta-cell replacement or regeneration strategies for the treatment of both type 1 and type 2 diabetes mellitus might fail if the correct cell signalling phenotype cannot be faithfully recreated. However, current understanding of beta-cell function is complicated because of the highly dynamic nature of their intracellular and intercellular signalling as well as insulin release itself. beta-Cells must precisely integrate multiple signals stemming from multiple cues, often with differing intensities, frequencies and cellular and subcellular localizations, before converging these signals onto insulin exocytosis. In this respect, optical approaches with high resolution in space and time are extremely useful for properly deciphering the complexity of beta-cell signalling. An increased understanding of beta-cell signalling might identify new mechanisms underlying insulin release, with relevance for future drug therapy and de novo stem cell engineering of functional islets.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Reviews Endocrinology

ISSN

1759-5029

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

721-737

Kód UT WoS článku

000449832300014

EID výsledku v databázi Scopus

2-s2.0-85055429349