New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00501560" target="_blank" >RIV/61388963:_____/19:00501560 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/19:00109325 RIV/62157124:16370/19:43877334

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0254629918308366?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0254629918308366?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sajb.2018.08.023" target="_blank" >10.1016/j.sajb.2018.08.023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.

Popis výsledku v původním jazyce

Three new compounds, diterpenoid glucoside (13S, 15S)-6 beta, 7 alpha, 12 alpha-trihydroxy-13 beta, 16-cyclo-8-abietene11,14- dione 7-O-beta-D-glucoside 1, flavonoids apigenin 7-O-(3''-O-acetyl)-beta-D-glucuronide 2 and apigenin 5-O( 3''-O-acetyl)-beta-D-glucuronide 3, together with known compounds caffeic acid 4, luteolin 5-O-beta-D-glucoside 5 and rosmarinic acid 6 were isolated from the aerial parts of Plectranthus scutellarioides (L.) R. Br. The structures of the new compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-and 2D-NMR. Compound 1 inhibited hyaluronidase by 25% at the concentration of 200 mu M, compounds 2 and 3 showed inhibitory activity on butyrylcholinesterase better than standard galanthamine at the concentration of 100 mu M, and compound 6 is a potent antioxidant with an ORAC value of 2.15 +/- 0.12. (c) 2018 SAAB. Published by Elsevier B. V. All rights reserved.

Název v anglickém jazyce

New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.

Popis výsledku anglicky

Three new compounds, diterpenoid glucoside (13S, 15S)-6 beta, 7 alpha, 12 alpha-trihydroxy-13 beta, 16-cyclo-8-abietene11,14- dione 7-O-beta-D-glucoside 1, flavonoids apigenin 7-O-(3''-O-acetyl)-beta-D-glucuronide 2 and apigenin 5-O( 3''-O-acetyl)-beta-D-glucuronide 3, together with known compounds caffeic acid 4, luteolin 5-O-beta-D-glucoside 5 and rosmarinic acid 6 were isolated from the aerial parts of Plectranthus scutellarioides (L.) R. Br. The structures of the new compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-and 2D-NMR. Compound 1 inhibited hyaluronidase by 25% at the concentration of 200 mu M, compounds 2 and 3 showed inhibitory activity on butyrylcholinesterase better than standard galanthamine at the concentration of 100 mu M, and compound 6 is a potent antioxidant with an ORAC value of 2.15 +/- 0.12. (c) 2018 SAAB. Published by Elsevier B. V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LM2011020" target="_blank" >LM2011020: CEITEC ? open access</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

South African Journal of Botany

ISSN

0254-6299

e-ISSN

—

Svazek periodika

120

Číslo periodika v rámci svazku

Jan

Stát vydavatele periodika

ZA - Jihoafrická republika

Počet stran výsledku

5

Strana od-do

286-290

Kód UT WoS článku

000456314600038

EID výsledku v databázi Scopus

2-s2.0-85053839580