The impact of anorexigenic peptides in experimental models of Alzheimer's disease pathology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00501595" target="_blank" >RIV/61388963:_____/19:00501595 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/19:00504220

Výsledek na webu

<a href="https://joe.bioscientifica.com/view/journals/joe/240/2/JOE-18-0532.xml" target="_blank" >https://joe.bioscientifica.com/view/journals/joe/240/2/JOE-18-0532.xml</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/JOE-18-0532" target="_blank" >10.1530/JOE-18-0532</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The impact of anorexigenic peptides in experimental models of Alzheimer's disease pathology

Popis výsledku v původním jazyce

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the elderly population. Numerous epidemiological and experimental studies have demonstrated that patients who suffer from obesity or type 2 diabetes mellitu s have a higher risk of cognitive dysfunction and AD. Several recent studies demonstrat ed that food intakelowering (anorexigenic) peptides have the potential to improve metabolic disorders and that they may also potentially be useful in the treatment of neurodegenerative diseases. In this review, the neuroprotective effects of anorexigenic pept ides of both peripheral and central origins are discussed. Moreover, the role of leptin as a key modulator of energy homeostasis is discussed in relation to its interaction with anorexigenic peptides and their analogs in AD-like pathology. Although there is no pe rfect experimental model of human AD pathology, animal studies have already proven that anorexigenic peptides exhibit neuroprotective properties. This phenomenon is extremely important for the potential development of new drugs in view of the aging of the human population and of the significantly increasing incidence of AD.

Název v anglickém jazyce

The impact of anorexigenic peptides in experimental models of Alzheimer's disease pathology

Popis výsledku anglicky

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the elderly population. Numerous epidemiological and experimental studies have demonstrated that patients who suffer from obesity or type 2 diabetes mellitu s have a higher risk of cognitive dysfunction and AD. Several recent studies demonstrat ed that food intakelowering (anorexigenic) peptides have the potential to improve metabolic disorders and that they may also potentially be useful in the treatment of neurodegenerative diseases. In this review, the neuroprotective effects of anorexigenic pept ides of both peripheral and central origins are discussed. Moreover, the role of leptin as a key modulator of energy homeostasis is discussed in relation to its interaction with anorexigenic peptides and their analogs in AD-like pathology. Although there is no pe rfect experimental model of human AD pathology, animal studies have already proven that anorexigenic peptides exhibit neuroprotective properties. This phenomenon is extremely important for the potential development of new drugs in view of the aging of the human population and of the significantly increasing incidence of AD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA16-00918S" target="_blank" >GA16-00918S: Neuroprotektivní účinky nových analogů anorektického peptidu uvolňujícího prolaktin (PrRP) v myších modelech neurodegenerace a obezity</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Endocrinology

ISSN

0022-0795

e-ISSN

—

Svazek periodika

240

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

26

Strana od-do

"R47"-"R72"

Kód UT WoS článku

000457095300001

EID výsledku v databázi Scopus

2-s2.0-85061809603