Rapid diffusion of cholesterol along polyunsaturated membranes via deep dives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00507305" target="_blank" >RIV/61388963:_____/19:00507305 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2019/CP/C9CP02022E#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/CP/C9CP02022E#!divAbstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c9cp02022e" target="_blank" >10.1039/c9cp02022e</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Rapid diffusion of cholesterol along polyunsaturated membranes via deep dives

Popis výsledku v původním jazyce

Cholesterol regulates the function of membrane proteins either via direct or membrane-mediated effects. Therefore, its ready availability is crucial for many protein-governed cellular processes. Recent studies suggest that cholesterol can partition to the core of polyunsaturated membranes, where cholesterol binding sites of many membrane proteins are also located. This core region is characterized by a lower viscosity. Therefore, we hypothesized that cholesterol partitioning into the membrane interior increases the rate of its diffusion in polyunsaturated membrane environments. We studied the behavior of cholesterol in membranes with increasing level of lipid chain unsaturation using a combination of atomistic and coarse-grained molecular dynamics simulations. Our simulations suggest a strong correlation between entropy-driven enhanced cholesterol partitioning to the membrane core and its faster lateral diffusion, which indicates that the less viscous membrane core indeed provides an efficient means for cholesterol movement in polyunsaturated membrane environments.

Název v anglickém jazyce

Rapid diffusion of cholesterol along polyunsaturated membranes via deep dives

Popis výsledku anglicky

Cholesterol regulates the function of membrane proteins either via direct or membrane-mediated effects. Therefore, its ready availability is crucial for many protein-governed cellular processes. Recent studies suggest that cholesterol can partition to the core of polyunsaturated membranes, where cholesterol binding sites of many membrane proteins are also located. This core region is characterized by a lower viscosity. Therefore, we hypothesized that cholesterol partitioning into the membrane interior increases the rate of its diffusion in polyunsaturated membrane environments. We studied the behavior of cholesterol in membranes with increasing level of lipid chain unsaturation using a combination of atomistic and coarse-grained molecular dynamics simulations. Our simulations suggest a strong correlation between entropy-driven enhanced cholesterol partitioning to the membrane core and its faster lateral diffusion, which indicates that the less viscous membrane core indeed provides an efficient means for cholesterol movement in polyunsaturated membrane environments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GX19-26854X" target="_blank" >GX19-26854X: Souhra lipidů, iontů a bílkovin a její role v dynamice a funkci buněčných membrán</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physical Chemistry Chemical Physics

ISSN

1463-9076

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

22

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

11660-11669

Kód UT WoS článku

000472218500010

EID výsledku v databázi Scopus

2-s2.0-85067129659