Using Polymers to Enhance the Carbon Nanomaterial Biointerface

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00521416" target="_blank" >RIV/61388963:_____/19:00521416 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/9781119373476.ch2" target="_blank" >http://dx.doi.org/10.1002/9781119373476.ch2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/9781119373476.ch2" target="_blank" >10.1002/9781119373476.ch2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Using Polymers to Enhance the Carbon Nanomaterial Biointerface

Popis výsledku v původním jazyce

This chapter focuses on functionalization of carbon nanomaterials (CNMs) with polymers for biomedical applications. A classical theoretical approach based on Derjaguin‐Landau‐Verwey‐Overbeek (DLVO) theory is commonly used to predict the stability of a colloidal system. CNMs can be functionalized with polymers via two types of approaches: noncovalent coating and covalent modification. The physicochemical properties of CNMs are determined by their intrinsic nanostructure. The chapter discusses the effect of polymer functionalization on the spectral properties of various CNMs. Stimuli‐responsive polymers respond to their environment by changing their physical and/or chemical properties. Among stimuli‐responsive polymers, thermoresponsive polymers have been exploited most abundantly to modify carbon nanoparticles. The development of nonviral, nonimmunogenic, and biocompatible vectors for efficient intracellular transfection of nucleic acids (NAs) is one of the challenges facing future gene therapy approaches. The surface of the CNMs can be functionalized by covalent or noncovalent attachment of macromolecular layers to create reliable nonviral gene delivery vectors.

Název v anglickém jazyce

Using Polymers to Enhance the Carbon Nanomaterial Biointerface

Popis výsledku anglicky

This chapter focuses on functionalization of carbon nanomaterials (CNMs) with polymers for biomedical applications. A classical theoretical approach based on Derjaguin‐Landau‐Verwey‐Overbeek (DLVO) theory is commonly used to predict the stability of a colloidal system. CNMs can be functionalized with polymers via two types of approaches: noncovalent coating and covalent modification. The physicochemical properties of CNMs are determined by their intrinsic nanostructure. The chapter discusses the effect of polymer functionalization on the spectral properties of various CNMs. Stimuli‐responsive polymers respond to their environment by changing their physical and/or chemical properties. Among stimuli‐responsive polymers, thermoresponsive polymers have been exploited most abundantly to modify carbon nanoparticles. The development of nonviral, nonimmunogenic, and biocompatible vectors for efficient intracellular transfection of nucleic acids (NAs) is one of the challenges facing future gene therapy approaches. The surface of the CNMs can be functionalized by covalent or noncovalent attachment of macromolecular layers to create reliable nonviral gene delivery vectors.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Carbon Nanomaterials for Bioimaging, Bioanalysis, and Therapy

ISBN

978-1-119-37345-2

Počet stran výsledku

28

Strana od-do

15-42

Počet stran knihy

376

Název nakladatele

Wiley

Místo vydání

Hoboken

Kód UT WoS kapitoly

—