Structure and function of naturally evolved de novo proteins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00540521" target="_blank" >RIV/61388963:_____/21:00540521 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/21:10438955

Výsledek na webu

<a href="https://doi.org/10.1016/j.sbi.2020.11.010" target="_blank" >https://doi.org/10.1016/j.sbi.2020.11.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sbi.2020.11.010" target="_blank" >10.1016/j.sbi.2020.11.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Structure and function of naturally evolved de novo proteins

Popis výsledku v původním jazyce

Comparative evolutionary genomics has revealed that novel protein coding genes can emerge randomly from non-coding DNA. While most of the myriad of transcripts which continuously emerge vanish rapidly, some attain regulatory regions, become translated and survive. More surprisingly, sequence properties of de novo proteins are almost indistinguishable from randomly obtained sequences, yet de novo proteins may gain functions and integrate into eukaryotic cellular networks quite easily. We here discuss current knowledge on de novo proteins, their structures, functions and evolution. Since the existence of de novo proteins seems at odds with decade-long attempts to construct proteins with novel structures and functions from scratch, we suggest that a better understanding of de novo protein evolution may fuel new strategies for protein design.

Název v anglickém jazyce

Structure and function of naturally evolved de novo proteins

Popis výsledku anglicky

Comparative evolutionary genomics has revealed that novel protein coding genes can emerge randomly from non-coding DNA. While most of the myriad of transcripts which continuously emerge vanish rapidly, some attain regulatory regions, become translated and survive. More surprisingly, sequence properties of de novo proteins are almost indistinguishable from randomly obtained sequences, yet de novo proteins may gain functions and integrate into eukaryotic cellular networks quite easily. We here discuss current knowledge on de novo proteins, their structures, functions and evolution. Since the existence of de novo proteins seems at odds with decade-long attempts to construct proteins with novel structures and functions from scratch, we suggest that a better understanding of de novo protein evolution may fuel new strategies for protein design.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GJ17-10438Y" target="_blank" >GJ17-10438Y: Evoluce sekvenčního a strukturního prostoru terestriálních bílkovin</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Structural Biology

ISSN

0959-440X

e-ISSN

1879-033X

Svazek periodika

68

Číslo periodika v rámci svazku

Jun

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

175-183

Kód UT WoS článku

000663831200021

EID výsledku v databázi Scopus

2-s2.0-85100636911