Cell-penetrating peptides in the intracellular delivery of viral nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00545044" target="_blank" >RIV/61388963:_____/21:00545044 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/21:10431295

Výsledek na webu

<a href="https://doi.org/10.1016/bs.vh.2021.06.010" target="_blank" >https://doi.org/10.1016/bs.vh.2021.06.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/bs.vh.2021.06.010" target="_blank" >10.1016/bs.vh.2021.06.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cell-penetrating peptides in the intracellular delivery of viral nanoparticles

Popis výsledku v původním jazyce

Cell-penetrating peptides (CPPs) are a promising tool for the intracellular delivery of cargo. Due to their ability to cross membranes while also cotransporting various cargoes, they offer great potential for biomedical applications. Several CPPs have been derived from viral proteins with natural roles in the viral replication cycle that require them to breach or fuse to cellular membranes. Additionally, the ability of viruses to cross membranes makes viruses and virus-based particles a convenient model for research on nanoparticle delivery and nanoparticle-mediated gene therapy. In this chapter, we aim to characterize CPPs derived from both structural and nonstructural viral proteins. Their function as enhancers of viral infection and transduction by viral nanoparticles as well as the main features of viral CPPs employed in intracellular cargo delivery are summarized to emphasize their potential use in nanomedicine.

Název v anglickém jazyce

Cell-penetrating peptides in the intracellular delivery of viral nanoparticles

Popis výsledku anglicky

Cell-penetrating peptides (CPPs) are a promising tool for the intracellular delivery of cargo. Due to their ability to cross membranes while also cotransporting various cargoes, they offer great potential for biomedical applications. Several CPPs have been derived from viral proteins with natural roles in the viral replication cycle that require them to breach or fuse to cellular membranes. Additionally, the ability of viruses to cross membranes makes viruses and virus-based particles a convenient model for research on nanoparticle delivery and nanoparticle-mediated gene therapy. In this chapter, we aim to characterize CPPs derived from both structural and nonstructural viral proteins. Their function as enhancers of viral infection and transduction by viral nanoparticles as well as the main features of viral CPPs employed in intracellular cargo delivery are summarized to emphasize their potential use in nanomedicine.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Hormones, regulators and viruses

ISBN

978-0-323-90731-6

Počet stran výsledku

30

Strana od-do

47-76

Počet stran knihy

332

Název nakladatele

Academic Press

Místo vydání

Cambridge

Kód UT WoS kapitoly

000750920700004