Light-activatable H2S donors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00570124" target="_blank" >RIV/61388963:_____/23:00570124 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/22:00133618

Výsledek na webu

<a href="https://doi.org/10.1002/9781119799900.ch14" target="_blank" >https://doi.org/10.1002/9781119799900.ch14</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/9781119799900.ch14" target="_blank" >10.1002/9781119799900.ch14</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Light-activatable H2S donors

Popis výsledku v původním jazyce

The chapter focuses on the release and delivery of hydrogen sulfide (H2S) from photoactivatable molecules using light as a biorthogonal trigger. We start with the introduction of photophysical and photochemical concepts related to their design. Standard methods of light delivery to human tissue and factors that limit the applicability of near-infrared irradiation wavelengths, allowing for deep tissue penetration, are subsequently reviewed. The most common methods of delivering light into the living organisms are briefly summarized and compared in the light of their clinical application. We show different mechanistic approaches to light-activated H2S release and provide a comprehensive survey of small organic molecules, organometallic complexes, supramolecular materials, and nanocomposites that can be used as H2S photodonors. The chapter concludes by highlighting the major challenges and obstacles to fuel future endeavors in the field of light-activated H2S donors.

Název v anglickém jazyce

Light-activatable H2S donors

Popis výsledku anglicky

The chapter focuses on the release and delivery of hydrogen sulfide (H2S) from photoactivatable molecules using light as a biorthogonal trigger. We start with the introduction of photophysical and photochemical concepts related to their design. Standard methods of light delivery to human tissue and factors that limit the applicability of near-infrared irradiation wavelengths, allowing for deep tissue penetration, are subsequently reviewed. The most common methods of delivering light into the living organisms are briefly summarized and compared in the light of their clinical application. We show different mechanistic approaches to light-activated H2S release and provide a comprehensive survey of small organic molecules, organometallic complexes, supramolecular materials, and nanocomposites that can be used as H2S photodonors. The chapter concludes by highlighting the major challenges and obstacles to fuel future endeavors in the field of light-activated H2S donors.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10401 - Organic chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies

ISBN

978-1-119-79987-0

Počet stran výsledku

26

Strana od-do

347-372

Počet stran knihy

560

Název nakladatele

John Wiley & Sons

Místo vydání

Hoboken

Kód UT WoS kapitoly

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