Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00573186" target="_blank" >RIV/61388963:_____/23:00573186 - isvavai.cz</a>

Výsledek na webu

<a href="https://worldwide.espacenet.com/patent/search/family/067070628/publication/EP3959208B1?q=EP3959208B1" target="_blank" >https://worldwide.espacenet.com/patent/search/family/067070628/publication/EP3959208B1?q=EP3959208B1</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

Popis výsledku v původním jazyce

The present invention relates to cyclen based compounds of general formula (I), wherein X is nitrogen and Y, Z are –CH-, or X, Z are –CH- and Y is nitrogen, or X, Y are –CH- and Z is nitrogen, R1 is independently selected from H, COOH, benzyloxycarbonyl, fluorenylmethyloxycarbonyl, tert-butoxycarbonyl, methylcarbonyl, trifluoromethylcarbonyl, benzyl, triphenylmethyl, tosyl, mesyl, benzyloxymethyl, phenylsulfonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R2 is selected from H, methylcarbonyl, tert-butyldimethylsilyl, (C1-C4)alkyl, which can be linear or branched, and which can optionally be substituted with CH3O-, CH3S-, oxacyclohexyl, allyl, tert-butyldiphenylsilyl, tert-butylcarbonyl, phenylcarbonyl, nitrobenzyl, benzyloxymethyl, which can optionally be substituted with CH3O-, -NO2, fluorenylmethyloxycarbonyl, trichlorocarbonyl, trifluorocarbonyl, benzyl, tosyl, mesyl, phenylsulfonyl, allylsulphonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R3 is independently selected from H, (C1-C6)alkyl, which can be linear or branched, and which can optionally be substituted with -CH3, -C1, -F, -CN, tosyl, triisopropylsilyl, CH3O-, CH3S-, (C5-C6)cycloalkyl, which can optionally be substituted with -CH3, -C1, -F, -CN, (C6-C10)aryl, which can optionally be substituted with -CH3, -C1, -F, -CN, allyl, propargyl, fluorenylmethyl, benzoylmethyl, phenyloxymethyl, oxacyclopentyl, 2-oxo-1,2-diphenylethyl, with the proviso that where R1 is bound to nitrogen, then R1 is not COOH, with the proviso that where R1 is bound to –CH-, then R1 is independently H or COOH, and with the proviso that one R1 is COOH, and with the proviso that one –CH-R1 group is –CH2-. The invention further relates to its coordination compounds, peptides and pharmaceutical preparations, as well as to the medical use thereof.

Název v anglickém jazyce

Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

Popis výsledku anglicky

The present invention relates to cyclen based compounds of general formula (I), wherein X is nitrogen and Y, Z are –CH-, or X, Z are –CH- and Y is nitrogen, or X, Y are –CH- and Z is nitrogen, R1 is independently selected from H, COOH, benzyloxycarbonyl, fluorenylmethyloxycarbonyl, tert-butoxycarbonyl, methylcarbonyl, trifluoromethylcarbonyl, benzyl, triphenylmethyl, tosyl, mesyl, benzyloxymethyl, phenylsulfonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R2 is selected from H, methylcarbonyl, tert-butyldimethylsilyl, (C1-C4)alkyl, which can be linear or branched, and which can optionally be substituted with CH3O-, CH3S-, oxacyclohexyl, allyl, tert-butyldiphenylsilyl, tert-butylcarbonyl, phenylcarbonyl, nitrobenzyl, benzyloxymethyl, which can optionally be substituted with CH3O-, -NO2, fluorenylmethyloxycarbonyl, trichlorocarbonyl, trifluorocarbonyl, benzyl, tosyl, mesyl, phenylsulfonyl, allylsulphonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R3 is independently selected from H, (C1-C6)alkyl, which can be linear or branched, and which can optionally be substituted with -CH3, -C1, -F, -CN, tosyl, triisopropylsilyl, CH3O-, CH3S-, (C5-C6)cycloalkyl, which can optionally be substituted with -CH3, -C1, -F, -CN, (C6-C10)aryl, which can optionally be substituted with -CH3, -C1, -F, -CN, allyl, propargyl, fluorenylmethyl, benzoylmethyl, phenyloxymethyl, oxacyclopentyl, 2-oxo-1,2-diphenylethyl, with the proviso that where R1 is bound to nitrogen, then R1 is not COOH, with the proviso that where R1 is bound to –CH-, then R1 is independently H or COOH, and with the proviso that one R1 is COOH, and with the proviso that one –CH-R1 group is –CH2-. The invention further relates to its coordination compounds, peptides and pharmaceutical preparations, as well as to the medical use thereof.

Druh

P - Patent

CEP obor

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OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/GJ17-22834Y" target="_blank" >GJ17-22834Y: Syntéza a screening selektivních kontrastních látek pro tomografii magnetické rezonance</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Číslo patentu nebo vzoru

EP3959208

Vydavatel

EPO_1 -

Název vydavatele

European Patent Office

Místo vydání

Munich, The Hague, Berlin, Vienna, Brussels

Stát vydání

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Datum přijetí

5. 7. 2023

Název vlastníka

Ústav organické chemie a biochemie AV ČR, v. v. i

Způsob využití

A - Výsledek využívá pouze poskytovatel

Druh možnosti využití

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence