Deoxyribozymes generating chemiluminescent signals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00587531" target="_blank" >RIV/61388963:_____/24:00587531 - isvavai.cz</a>

Výsledek na webu

<a href="https://worldwide.espacenet.com/patent/search/family/074625815/publication/EP4043566B1?q=EP4043566B1" target="_blank" >https://worldwide.espacenet.com/patent/search/family/074625815/publication/EP4043566B1?q=EP4043566B1</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Deoxyribozymes generating chemiluminescent signals

Popis výsledku v původním jazyce

The present invention relates to self-phosphorylating deoxyribozymes containing or consisting of the nucleotide sequence: 5'-X1X2X3AX4X5-R1X6X7X8X9X10-bp1-helix1-R2-helix2-bp2-X11TGACX12TGGGAX13-helix3-X14-R3-3' (SEQ ID NO. 1) wherein X1 is G or T, X2 is G or T, X3 is A or C, X4 is G or T, X5 is A or T, X6 is G or T or A, X7 is A or C or G or T, X8 is A or G or T, X9 is T or C or A or G, X10 is A or T or G, X11 is G or A, X12 is T or C or G, X13 is T or G or C, X14 is G or A or C or T, R1 represents a nucleotide sequence containing 3 to 30 nucleotides, R2 represents a nucleotide sequence containing 3 to 30 nucleotides, R3 represents a nucleotide sequence containing 0 to 30 nucleotides, bp1 and bp2 are nucleotides selected from G, A, C, T, which together form a base pair, helix1, helix2, and helix3 each independently denotes a nucleotide sequence preferably containing 4 or more nucleotides, wherein helix 1, helix2, and helix3 together form a triple helical structure. The deoxyribozymes of the present invention may be used for detection of chemiluminescent substrates, or for detection of analytes (ligands) based on chemiluminescent reaction of the substrates catalyzed by the deoxyribozymes.

Název v anglickém jazyce

Deoxyribozymes generating chemiluminescent signals

Popis výsledku anglicky

The present invention relates to self-phosphorylating deoxyribozymes containing or consisting of the nucleotide sequence: 5'-X1X2X3AX4X5-R1X6X7X8X9X10-bp1-helix1-R2-helix2-bp2-X11TGACX12TGGGAX13-helix3-X14-R3-3' (SEQ ID NO. 1) wherein X1 is G or T, X2 is G or T, X3 is A or C, X4 is G or T, X5 is A or T, X6 is G or T or A, X7 is A or C or G or T, X8 is A or G or T, X9 is T or C or A or G, X10 is A or T or G, X11 is G or A, X12 is T or C or G, X13 is T or G or C, X14 is G or A or C or T, R1 represents a nucleotide sequence containing 3 to 30 nucleotides, R2 represents a nucleotide sequence containing 3 to 30 nucleotides, R3 represents a nucleotide sequence containing 0 to 30 nucleotides, bp1 and bp2 are nucleotides selected from G, A, C, T, which together form a base pair, helix1, helix2, and helix3 each independently denotes a nucleotide sequence preferably containing 4 or more nucleotides, wherein helix 1, helix2, and helix3 together form a triple helical structure. The deoxyribozymes of the present invention may be used for detection of chemiluminescent substrates, or for detection of analytes (ligands) based on chemiluminescent reaction of the substrates catalyzed by the deoxyribozymes.

Druh

P - Patent

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Číslo patentu nebo vzoru

EP4043566

Vydavatel

EPO_1 -

Název vydavatele

European Patent Office

Místo vydání

Munich, The Hague, Berlin, Vienna, Brussels

Stát vydání

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Datum přijetí

10. 4. 2024

Název vlastníka

Ústav organické chemie a biochemie AV ČR, v. v. i.

Způsob využití

A - Výsledek využívá pouze poskytovatel

Druh možnosti využití

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence