Insulin-like hormone derivatives in physiology and disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00602499" target="_blank" >RIV/61388963:_____/24:00602499 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Insulin-like hormone derivatives in physiology and disease

Popis výsledku v původním jazyce

Peptide hormones of the insulin family (insulin, IGF-1 and IGF-2), together with their receptors and binding proteins, represent a complex protein system that plays important roles in the development and growth of the organism and in the regulation of the overall metabolic balance. Deregulation of this system can cause serious health complications ranging from the development of cancer, neurological diseases to diabetes mellitus. Our laboratory is involved in the synthesis and characterization of insulin-like hormone derivatives to study their interaction with receptors and to develop new compounds that could find application in the treatment of insulin and IGF-related diseases. We will present our results in the development of insulin derivatives with altered specificity towards receptors for insulin, IGF-1 and IGF-2, and the biological properties of peptides derived from IGF-2 precursors. An overview of our activities in the field of development of derivatives of biologically active peptides from the insulin-like family will be presented.

Název v anglickém jazyce

Insulin-like hormone derivatives in physiology and disease

Popis výsledku anglicky

Peptide hormones of the insulin family (insulin, IGF-1 and IGF-2), together with their receptors and binding proteins, represent a complex protein system that plays important roles in the development and growth of the organism and in the regulation of the overall metabolic balance. Deregulation of this system can cause serious health complications ranging from the development of cancer, neurological diseases to diabetes mellitus. Our laboratory is involved in the synthesis and characterization of insulin-like hormone derivatives to study their interaction with receptors and to develop new compounds that could find application in the treatment of insulin and IGF-related diseases. We will present our results in the development of insulin derivatives with altered specificity towards receptors for insulin, IGF-1 and IGF-2, and the biological properties of peptides derived from IGF-2 precursors. An overview of our activities in the field of development of derivatives of biologically active peptides from the insulin-like family will be presented.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů